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Encapsulation of bilayer vesicles by self-assembly

机译：通过自组装包封双层囊泡

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摘要

Vesicles of lipid bilayers have been investigated as drug-delivery vehicles for almost 20 years. The vesicles' interior space is separated from the surrounding solution because small molecules have only limited permeability through the bilayer. Single-walled (unilamellar) vesicles are made by a variety of non-equilibrium techniques, including mechanical disruption of lamellar phases by sonication or extrusion through filters, or chemical disruption by detergent dialysis or solvent removal. These techniques do not, however, allow the encapsulation of a specific volume, nor can they be used to encapsulate other vesicles. Here we show that molecular-recognition processes mediated by lipophilic receptors and substrates (here the biotin-streptavidin complex) can be used to produce a multicompartmental aggregate of tethered vesicles encapsulated within a large bilayer vesicle. We call these encapsulated aggregates vesosomes. Encapsulation is achieved by unrolling bilayers from cochleate cylinderss which are tethered to the aggregate by biotin-streptavidin coupling. These compartmentalized vesosomes could provide vehicles for multicomponent or multifunctional drug delivery; in particular, the encapsulating membrane could significantly modify permeation properties, or could be used to enhance the biocompatibility of the system.
机译：脂质双层的囊泡已经作为药物递送载体进行了近20年的研究。囊泡的内部空间与周围溶液分开，因为小分子通过双层的渗透性有限。单壁（单层）囊泡是通过各种非平衡技术制成的，包括通过超声处理或通过过滤器挤出来机械破坏层状相，或通过去污剂透析或去除溶剂来破坏化学作用。然而，这些技术不允许包封特定体积，也不能用于包封其他囊泡。在这里，我们显示了由亲脂性受体和底物（在这里是生物素-链霉亲和素复合物）介导的分子识别过程可用于生产封装在大双层囊泡中的束缚囊泡的多室聚集体。我们称这些封装的聚集体为囊泡。包封是通过从蜗壳圆柱体上展开双层而实现的，而蜗壳通过生物素-链霉亲和素偶联而束缚在聚集体上。这些分隔的囊泡可以为多组分或多功能药物输送提供载体。特别地，包封膜可显着改变渗透性能，或可用于增强系统的生物相容性。

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