• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Nature >A biosensor that uses ion-channel switches
【24h】

A biosensor that uses ion-channel switches

机译：使用离子通道开关的生物传感器

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Biosensors are molecular sensors that combine a biological recognition mechanism with a physical transduction technique. They provide a new class of inexpensive, portable instrument that permit sophisticated analytical measurements to be undertaken rapidly at decentralized locations. However, the adoption of biosensors for practical applications other than the measurement of blood glucose is currently limited by the expense, insensitivity and inflexibility of the available transduction methods. Here we describe the development of a biosensing technique in which the conductance of a population of molecular ion channels is switched by the recognition event. The approach mimics biological sensory functions and can be used with most types of receptor, including antibodies and nucleotides. The technique is very flexible and even in its simplest form it is sensitive to picomolar concentrations of proteins. The sensor is essentially an impedance element whose dimensions can readily be reduced to become an integral component of a microelectronic circuit. It may be used in a wide range of applications and in complex media, including blood. These uses might include cell typing, the detection of large proteins, viruses, antibodies, DNA, electrolytes, drugs, pesticides and other low-molecular-weight compounds.
机译：生物传感器是结合了生物识别机制和物理转导技术的分子传感器。它们提供了新型的廉价便携式仪器，可在分散的位置快速进行复杂的分析测量。然而，目前除了测量血糖以外，将生物传感器用于实际应用还受到可用转导方法的费用，不敏感性和不灵活性的限制。在这里，我们描述了一种生物传感技术的发展，其中通过识别事件来切换分子离子通道的电导率。该方法模仿生物学的感觉功能，可用于大多数类型的受体，包括抗体和核苷酸。该技术非常灵活，即使以最简单的形式，也对皮摩尔浓度的蛋白质敏感。传感器本质上是阻抗元件，其尺寸可以容易地减小以成为微电子电路的组成部分。它可以用于广泛的应用和复杂的介质，包括血液。这些用途可能包括细胞分型，检测大蛋白，病毒，抗体，DNA，电解质，药物，杀虫剂和其他低分子量化合物。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号