Rhodopsin evolution in the dark

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Rhodopsin evolution in the dark

机译：视紫红质在黑暗中的进化

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The gene for the visual pigment rhodopsin has been extensively studied from biochemical, molecular and evolutionary perspectives. This makes it ideal for investigating the relationship between protein structure and function, and the effects of loss offunctional constraint on the evolution of a gene. We specifically addressed the question of what happens when there is no light available by studying rhodopsin genes from three pairs of cave-dwelling and surface-dwelling freshwater crayfish species. Contrary to predictions, we found no differences in the rate of evolution between the cave and surface species or between the conserved and variable structural motifs of the rhodopsin protein. This suggests that rhodopsin might have a previously unknown function in the absence of light.

机译：视觉色素视紫红质的基因已从生化，分子和进化的角度进行了广泛的研究。这使得它非常适合研究蛋白质结构与功能之间的关系以及功能限制缺失对基因进化的影响。我们通过研究来自三对洞穴居住和表面居住的淡水小龙虾物种的视紫红质基因，专门解决了当无光时会发生什么的问题。与预测相反，我们发现洞和表层物种之间或视紫红质蛋白的保守和可变结构基序之间的进化速率没有差异。这表明视紫红质在没有光照的情况下可能具有以前未知的功能。

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《Nature》 |1997年第6634期|p.667-668|共2页
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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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正文语种 eng
中图分类自然科学总论;
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1. Recoverin inhibits the phosphorylation of dark-adapted rhodopsin more than it does that of bleached rhodopsin: A possible mechanism through which rhodopsin kinase is prevented from participation in a side reaction [J] . Senin II, Dean KR, Zargarov AA, The Biochemical Journal . 1997,第Pta2期

机译：恢复蛋白对暗适应性视紫红质的磷酸化作用比对漂白视紫红质的磷酸化作用更强：一种可能的机制，可防止视紫红质激酶参与副反应
2. Recoverin inhibits the phosphorylation of dark-adapted rhodopsin more than it does that of bleached rhodopsin: a possible mechanism through which rhodopsin kinase is prevented from participation in a side reaction [J] . Aminullah A. ZARGAROV, Ivan I. SENIN, Kevin R. DEAN, The biochemical journal . 1997,第2期

机译：恢复蛋白对暗适应性视紫红质的磷酸化作用比对漂白视紫红质的磷酸化具有更多的抑制作用：一种可能的机制，可以防止视紫红质激酶参与副反应
3. Rhodopsin kinase and arrestin binding control the decay of photoactivated rhodopsin and dark adaptation of mouse rods [J] . Rikard Frederiksen, Soile Nymark, Alexander V. Kolesnikov, The Journal of general physiology . 2016,第1期

机译：视紫红质激酶和抑制蛋白的结合控制光活化视紫红质的衰变和小鼠视杆的暗适应
4. Three-layer ONIOM Studies of Rhodopsin in the Dark State: Shedding Light on the Protonation State of Glu-181 [C] . Katherine F. Hall, Thom Vreven, Michael J. Frisch, International Conference of Computational Methods in Sciences and Engineering 2007(ICCMSE 2007); 20070925-30; Corfu(GR) . 2007

机译：视紫红质在黑暗状态下的三层ONIOM研究：Glu-181质子化状态的亮光
5. Evolution of Retinylidene Proteins: Relocating the Active-Site Lysine in Rhodopsin. [D] . Devine, Erin Lynn. 2016

机译：视黄叉蛋白的进化：在视紫红质中重新定位活性位赖氨酸。
6. Recoverin inhibits the phosphorylation of dark-adapted rhodopsin more than it does that of bleached rhodopsin: a possible mechanism through which rhodopsin kinase is prevented from participation in a side reaction. [O] . I I Senin, K R Dean, A A Zargarov, 1997

机译：恢复蛋白对暗适应性视紫红质的磷酸化作用比对漂白视紫红质的磷酸化具有更多的抑制作用：这是一种防止视紫红质激酶参与副反应的可能机制。
7. Recoverin inhibits the phosphorylation of dark-adapted rhodopsin more than it does that of bleached rhodopsin: a possible mechanism through which rhodopsin kinase is prevented from participation in a side reaction. [O] . Senin, I I, Dean, K R, Zargarov, A A, 1997

机译：恢复蛋白对暗适应性视紫红质的磷酸化作用比对漂白视紫红质的磷酸化具有更多的抑制作用：这是一种防止视紫红质激酶参与副反应的可能机制。

Rhodopsin evolution in the dark

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