A cytokine-responsive IκB kinase that activates the transcription factor NF-κB

Joseph A. DiDonato; Makio Hayakawa; David M. Rothwarf; Ebrahim Zandi; Michael Karin

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A cytokine-responsive IκB kinase that activates the transcription factor NF-κB

机译：激活转录因子NF-κB的细胞因子反应性IκB激酶

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Nuclear transcription factors of the NF-κB/Rel family are inhibited by IκB proteins, which inactivate NF-κB by trapping it in the cell cytoplasm. Phosphorylation of IκBs marks them out for destruction, thereby relieving their Inhibitory effect on NF-κB. A cytokine-activated protein kinase complex, IKK (for IκB kinase), has now been purified that phosphorylates IκBs on the sites that trigger their degradation. A component of IKK was molecularly cloned and identified as a serine kinase. IKK turns out to be the long-sought-after protein kinase that mediates the critical regulatory step in NF-κB activation.

机译：NF-κB/ Rel家族的核转录因子受到IκB蛋白的抑制，该蛋白通过将NF-κB捕获在细胞质中而使其失活。 IκB的磷酸化将其标记为被破坏，从而减轻了它们对NF-κB的抑制作用。现在已经纯化了一种细胞因子激活的蛋白激酶复合物IKK（用于IκB激酶），该蛋白使触发其降解的位点上的IκB磷酸化。分子克隆了IKK的一种成分，并将其鉴定为丝氨酸激酶。事实证明，IKK是介导NF-κB激活关键调节步骤的人们期待已久的蛋白激酶。

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《Nature》 |1997年第6642期|p.548-554|共7页
作者
Joseph A. DiDonato; Makio Hayakawa; David M. Rothwarf; Ebrahim Zandi; Michael Karin;
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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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正文语种 eng
中图分类自然科学总论;
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A cytokine-responsive IκB kinase that activates the transcription factor NF-κB

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