Anaesthetics set their sites on ion channels

N. P. Franks; W. R. Lieb

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Anaesthetics set their sites on ion channels

机译：麻醉药在离子通道上定位

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The way in which volatile and gasecus general anaesthetics work has remained a puzzle ever since they were introduced into clinical practice during the 1840s. The prevailing view has been that anaesthetics (and, indeed, alcohol) do not have specific molecular targets in the conventional pharmacological sense, but that they nonspecifically disrupt nerve-membrane lipids. Evidence in support of this includes the molecular simplicity of the agents, and the correlation of potency with fat solubility.

机译：自从1840年代将其引入临床实践以来，挥发性和Gasecus全身麻醉剂的工作方式一直是一个难题。普遍的看法是，在常规药理学意义上，麻醉剂（实际上是酒精）没有特定的分子靶标，但它们非特异性地破坏神经膜脂质。支持这一点的证据包括试剂的分子简单性，以及药效与脂肪溶解度的关系。

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《Nature》 |1997年第6649期|p.334-335|共2页
作者
N. P. Franks; W. R. Lieb;
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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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正文语种 eng
中图分类自然科学总论;
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1. A mutation in the local anaesthetic binding site abolishes toluene effects in sodium channels. [J] . Gauthereau MY, Salinas Stefanon EM, Cruz SL European Journal of Pharmacology: An International Journal . 2005,第1a3期

机译：局部麻醉剂结合位点的突变消除了钠通道中的甲苯效应。
2. Volatile anaesthetics restore bradykinin and serotonin-induced coronary vasodilation after blocking nitric oxide synthase: lack of anaesthetic effects on KATP channels and prostaglandin pathways. [J] . Stowe DF, Heisner JS, Chung WW, European journal of anaesthesiology . 2001,第4期

机译：挥发性麻醉药在阻断一氧化氮合酶后恢复了缓激肽和5-羟色胺诱导的冠状血管舒张作用：对KATP通道和前列腺素途径的麻醉作用不足。
3. Suppression of insulin signalling by a synthetic peptide KIFMK suggests the cytoplasmic linker between DIII-S6 and DIV-S1 as a local anaesthetic binding site on the sodium channel. [J] . Hirose M, Kuroda Y, Sawa S, British Journal of Pharmacology . 2004,第1期

机译：合成肽KIFMK对胰岛素信号的抑制表明DIII-S6和DIV-S1之间的胞质接头是钠通道上的局部麻醉剂结合位点。
4. The bone marrow as a site for the reception of infusions, transfusions and anaesthetic agents [C] . M. Goerig, K. Agarwal-Koslowski World Congress on In Vitro Fertilization and Molecular Reproduction . 2002

机译：骨髓作为接受输注，输血和麻醉剂的遗址
5. A Strategy for Classifying a Set of Dissimilar Channels by Their A Priori Channel Occupancy Probability. [D] . Sugrim, Shridatt. 2014

机译：通过先验信道占用率对一组不同信道进行分类的策略。
6. Inhalational anaesthetics and n-alcohols share a site of action in the neuronal Shaw2 Kv channel [O] . Aditya Bhattacharji, Nathan Klett, Ramon Christopher V Go, 2010

机译：吸入麻醉药和正醇在神经元Shaw2 Kv通道中共有一个作用部位
7. Finding the Route of Entry and Binding Site of Local Anaesthetics in Bacterial Voltage Gated Sodium Channels Using Molecular Dynamics Simulation [O] . Martin Lewis, Corry Ben 2014

机译：利用分子动力学模拟寻找细菌电压门控钠通道中局麻药的进入和结合位点

Anaesthetics set their sites on ion channels

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