STRUCTURE AND MECHANISM OF DNA TOPOISOMERASE II

Berger JM.; Harrison SC.; Wang JC.; Gamblin SJ.

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STRUCTURE AND MECHANISM OF DNA TOPOISOMERASE II

机译：DNA拓扑异构酶II的结构和机制

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The crystal structure of a large fragment of yeast type II DNA topoisomerase reveals a heart-shaped dimeric protein with a large central hole. It provides a molecular model of the enzyme as an ATP-modulated clamp with two sets of jaws at opposite ends, connected by multiple joints. An enzyme with bound DNA can admit a second DNA duplex through one set of jaws, transport it through the cleaved first duplex, and expel it through the other set of jaws. [References: 43]

机译：酵母II型DNA拓扑异构酶大片段的晶体结构揭示了一个带有大中心孔的心形二聚体蛋白。它提供了一种作为ATP调节夹具的酶的分子模型，该夹具在相对的两端具有两组通过多个关节相连的钳口。具有结合的DNA的酶可以使第二个DNA双链体通过一组钳口进入，通过切割的第一条双链体运输，然后通过另一组钳口排出。 [参考：43]

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来源
《Nature》 |1996年第6562期|p. 225-232|共8页
作者
Berger JM.; Harrison SC.; Wang JC.; Gamblin SJ.;
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作者单位

WHITEHEAD INST BIOMED RES 9 CAMBRIDGE CTR CAMBRIDGE MA 02142 USA;

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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
关键词
Gyrase-b-protein; Crystal-structure; Escherichia-coli; Saccharomyces-cerevisiae; Gene; Purification; Complexes; Homology; Sequence; Fragment;

机译：促旋酶b蛋白;晶体结构;大肠杆菌;酿酒酵母;基因;纯化;复合物;同源性;序列;片段;

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专利

1. The structure of DNA-bound human topoisomerase II alpha: Conformational mechanisms for coordinating inter-subunit interactions with DNA cleavage [J] . WendorffT.J., SchmidtB.H., HeslopP., Journal of Molecular Biology . 2012,第3a4期

机译：DNA绑定的人类拓扑异构酶IIα的结构：协调亚基间相互作用与DNA切割的构象机制。
2. Structure of an 'open' clamp type II topoisomerase-DNA complex provides a mechanism for DNA capture and transport [J] . Laponogov Ivan, Veselkov Dennis A., Crevel Isabelle M. -T., Nucleic Acids Research . 2013,第21期

机译：“开放式” II型钳形拓扑异构酶-DNA复合物的结构为DNA捕获和运输提供了一种机制
3. Structure of an ‘open' clamp type II topoisomerase-DNA complex provides a mechanism for DNA capture and transport [J] . Dennis A. Veselkov, Isabelle M.-T. Crevel, Ivan Laponogov, Nucleic acids research . 2013,第21期

机译：“开放式” II型钳位拓扑异构酶-DNA复合物的结构为DNA捕获和运输提供了一种机制
4. DNA topoisomerases II: Evolution of their ATP bining site and design of new inhibitors [C] . L.Assairi Chinese peptide symposium . 1998

机译：DNA Topoisomerases II：其ATP啤酒网站的演变和新抑制剂的设计
5. Type II topoisomerase-DNA interactions: Structure, mechanism, and covalent trapping. [D] . Ruthenburg, Alexander Jackson. 2005

机译：II型拓扑异构酶与DNA的相互作用：结构，机理和共价捕获。
6. The Structure of DNA-Bound Human Topoisomerase II Alpha: Conformational Mechanisms for Coordinating Inter-Subunit Interactions with DNA Cleavage [O] . Timothy J. Wendorff, Bryan H. Schmidt, Pauline Heslop, -1

机译：DNA结合人拓扑异构酶IIα的结构：构象机制与DNA切割协调亚基间相互作用
7. The Structure of DNA-Bound Human Topoisomerase II Alpha: Conformational Mechanisms for Coordinating Inter-Subunit Interactions with DNA Cleavage [O] . Wendorff Timothy J., Schmidt Bryan H., Heslop Pauline, 2012

机译：DNA绑定人类拓扑异构酶II Alpha的结构：构象机制与DNA切割协调亚基间的相互作用。
8. Compositions and Methods for the Detection of DNA Topoisomerase II Complexes with DNA. [R] . Felix, C. A., Baldwin, D. A. 2005

机译：用于检测DNa拓扑异构酶II与DNa的复合物的组合物和方法。

STRUCTURE AND MECHANISM OF DNA TOPOISOMERASE II

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