RNA BINDING AND TRANSLATIONAL SUPPRESSION BY BICOID

Riverapomar R.; Schmidtott U.; Gehring WJ.; Jackle H.; Niessing D.

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RNA BINDING AND TRANSLATIONAL SUPPRESSION BY BICOID

机译：双生RNA的RNA结合和翻译抑制

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THE anterior determinant bicoid (bcd) of Drosophila is a homeodomain protein. It forms an anterior-to-posterior gradient in the embryo and activates, in a concentration-dependent manner, several zygotic segmentation genes during blastoderm formation(1-4). Its posterior counterpart, the homeodomain transcription factor caudal (cad)(5-7), forms a concentration gradient in the opposite direction, emanating from evenly distributed messenger RNA in the egg. In embryos lacking bcd activity as a result of mutation, the cad gradient fails to form and cad becomes evenly distributed throughout the embryo(8). This suggests that bcd may act in the region-specific control of cad mRNA translation. Here we report that bcd binds through its homeodomain to cad mRNA in vitro, and exerts translational control through a bcd-binding region of cad mRNA. [References: 29]

机译：果蝇的前决定簇二倍体（bcd）是一个同源域蛋白。它在胚中形成从前到后的梯度，并在胚盘形成过程中以浓度依赖的方式激活多个合子分割基因（1-4）。其后部对应的同源结构域转录因子尾（cad）（5-7）在相反方向上形成浓度梯度，这是由蛋中均匀分布的信使RNA引起的。在由于突变而缺乏bcd活性的胚胎中，cad梯度无法形成，并且cad均匀分布在整个胚胎中（8）。这表明bcd可能在cad mRNA翻译的区域特异性控制中起作用。在这里，我们报道bcd体外通过其同源域与cad mRNA结合，并通过cad mRNA的bcd结合区发挥翻译控制作用。 [参考：29]

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来源
《Nature》 |1996年第6567期|p. 746-749|共4页
作者
Riverapomar R.; Schmidtott U.; Gehring WJ.; Jackle H.; Niessing D.;
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作者单位

MAX PLANCK INST BIOPHYS CHEM ABT MOLEK ENTWICKLUNGSBIOL FASSBERG D-37077 GOTTINGEN GERMANY;

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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
关键词
Segmentation gene hunchback; Drosophila embryos; Body pattern; Gradient; Protein; Transcription; Expression; Kruppel; Localization; Anterior;

机译：分段基因驼背;果蝇胚胎;体型;梯度;蛋白质;转录;表达;Kruppel;定位;前;

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专利

1. MicroRNAs Act as Cofactors in Bicoid-Mediated Translational Repression [J] . Roedel Claudia J., Gilles Anna F., Averof Michalis Current Biology: CB . 2013,第16期

机译：MicroRNA在类比杆介导的翻译抑制中充当辅助因子。
2. The bicoid mRNA localization factor Exuperantia is an RNA-binding pseudonuclease [J] . Lazzaretti Daniela, Veith Katharina, Kramer Katharina, Nature structural & molecular biology . 2016,第8期

机译：bicoid mRNA本地化因子Exuperantia是一种RNA结合假核酸酶
3. Recognition of a bicoid mRNA Localization Signal by a Protein Complex Containing Swallow, Nod, and RNA Binding Proteins [J] . Eric A. Arn, Byeong J. Cha, William E. Theurkauf, Developmental cell . 2003,第1期

机译：包含燕子，Nod和RNA结合蛋白的蛋白质复合体识别双曲面mRNA定位信号。
4. A deep neural network approach using distributed representations of RNA sequence and structure for identifying binding site of RNA-binding proteins [C] . Lei Deng, Youzhi Liu, Yechuan Shi, IEEE International Conference on Bioinformatics and Biomedicine . 2019

机译：使用RNA序列和结构的分布式表示的深层神经网络方法，用于识别RNA结合蛋白的结合位点
5. Role of the RNA-Binding Protein UBP1C in Translational Repression During Hypoxia in Arabidopsis thaliana. [D] . Sorenson, Reed Stephen. 2012

机译：RNA结合蛋白UBP1C在拟南芥低氧期间的翻译抑制中的作用。
6. Sequence interval within the PEST motif of Bicoid is important for translational repression of caudal mRNA in the anterior region of the Drosophila embryo. [O] . D Niessing, N Dostatni, H Jäckle, 1999

机译：Bicoid的PEST母题中的序列间隔对于果蝇胚胎前区尾状mRNA的翻译抑制非常重要。
7. MicroRNAs Act as Cofactors in Bicoid-Mediated Translational Repression [O] . Rödel Claudia J., Gilles Anna F., Averof Michalis 2013

机译：MicroRNA在双曲线介导的翻译抑制中充当辅助因子。

RNA BINDING AND TRANSLATIONAL SUPPRESSION BY BICOID

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