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首页> 外文期刊>Nature >CHARACTERIZATION OF A CANCER CACHECTIC FACTOR
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CHARACTERIZATION OF A CANCER CACHECTIC FACTOR

机译：癌性因素的表征

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CANCER cachexia is a syndrome of progressive wasting which has been suggested to be mediated by tumour-necrosis factor-alpha (ref. 1), interleukins 1 and 6 (ref. 2), interferon-gamma (ref. 3) and leukaemia-inhibitory factor(4). It has proved difficult to correlate levels of tumour-necrosis factor-alpha and interleukin-6 with cancer cachexia(5,6), and the weight loss induced by leukaemia-inhibitory factor may be due to toxicity(7). In the murine adenocarcinoma MAC16, cachexia is mediated by circulatory catabolic factors(8,9), which we have now isolated using an antibody cloned from splenocytes of mice transplanted with the MAC16 tumour, with a delayed cachexia(10). The material is a proteoglycan of relative molecular mass 24K which produces cachexia in vivo by inducing catabolism of skeletal muscle. The 24K material was also present in urine of cachectic cancer patients, but was absent from normal subjects, patients with weight loss due to trauma, and cancer patients with little or no weight loss. This suggests that cachexia in mice and humans may be produced by the same material. [References: 17]
机译：癌症恶病质是一种进行性消耗的综合征，已被认为是由肿瘤坏死因子-α（参考文献1），白介素1和6（参考文献2），干扰素-γ（参考文献3）和白血病抑制作用介导的。因素（4）。已证明很难将肿瘤坏死因子α和白介素6的水平与癌症恶病质相关（5,6），并且由白血病抑制因子引起的体重减轻可能是由于毒性引起的（7）。在鼠腺癌MAC16中，恶病质是由循环分解代谢因子介导的（8,9），我们现在已经使用从MAC16肿瘤移植的小鼠脾细胞中克隆的抗体分离出了恶病质（10）。该物质是相对分子质量为24K的蛋白聚糖，通过诱导骨骼肌分解代谢而在体内产生恶病质。恶病质癌症患者的尿液中也存在24K物质，但正常受试者，因外伤导致体重减轻的患者以及体重减轻很少或没有体重减轻的癌症患者不存在24K材料。这表明小鼠和人类的恶病质可能由相同的物质产生。 [参考：17]

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