首页> 外文期刊>Nature >ESSENTIAL ROLE OF THE POSTERIOR MORPHOGEN NANOS FOR GERMLINE DEVELOPMENT IN DROSOPHILA
【24h】

ESSENTIAL ROLE OF THE POSTERIOR MORPHOGEN NANOS FOR GERMLINE DEVELOPMENT IN DROSOPHILA

机译:后期形态发生态纳米在果蝇生殖发育中的重要作用

获取原文
获取原文并翻译 | 示例
           

摘要

IN many animal groups, factors required for germline formation are localized in germ plasm(1), a region of the egg cytoplasm, In Drosophila embryos, germ plasm is located in the posterior pole region and is inherited in pole cells, the germline progenitors. Transplantation experiments have demonstrated that germ plasm contains factors that can form germline(2-4), and germ plasm also directs abdomen formation(5). Genetic analysis has shown that a common mechanism directs the localization of the abdomen and germline-forming factors to the posterior pole(6-12). The critical factor for abdomen formation is the nanos (nos) protein (nanos)(13-15). Here we show that nos is also essential for germline formation in Drosophila; pole cells lacking nanos activity fail to migrate into the gonads, and so do not become functional germ cells. In such pole cells, gene expression, which normally initiates within the gonad, begins prematurely during pole cell migration. Premature activation of genes in germline precursors may mean that these cells fail to develop normally. A function for nos protein in Drosophila germline formation is compatible with observations of its association with germ plasm in other animals(16-18). [References: 29]
机译:在许多动物群中,种系形成所需的因子位于种质(1)(卵细胞质的一个区域)中。在果蝇胚胎中,种质位于后极区,并在种质祖先极细胞中遗传。移植实验表明,种质中含有可以形成种系的因子(2-4),并且种质还可以指导腹部的形成(5)。遗传分析表明,一种常见的机制将腹部和种系形成因子的定位引导至后极(6-12)。腹部形成的关键因素是纳米(nos)蛋白(nanos)(13-15)。在这里,我们显示果蝇在果蝇种系形成中也没有必不可少的条件。缺乏纳米活性的极细胞无法迁移到性腺中,因此不会成为功能性生殖细胞。在这种极细胞中,通常在性腺中起始的基因表达在极细胞迁移过程中过早开始。种系前体中基因的过早激活可能意味着这些细胞无法正常发育。果蝇种系形成中nos蛋白的功能与其在其他动物中与种质的相关性相一致(16-18)。 [参考:29]

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号