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ADAPTIVE INDUCIBILITY OF CREM AS TRANSCRIPTIONAL MEMORY OF CIRCADIAN RHYTHMS

机译：CREM作为Circadian节律的转录记忆的自适应诱导性

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摘要

THE CREM gene(1-4) encodes the transcriptional repressor ICER(3,5), which has been implicated in the molecular mechanisms controlling circadian rhythms in mammals(4-6). ICER is rhythmically expressed in the pineal gland, with peak levels occurring at night(5). ICER levels are regulated by light by means of the suprachiasmatic nucleus (SCN); transcription is induced during darkness by adrenergic input to the pineal gland from the SCN, which activates the ICER promoter using cyclic AMP and the transcriptional activator CREB. This induction is transient because ICER represses its own transcription(3), Here we show that the response of the CREM gene to adrenergic stimulation is determined by night length, Depending on the photoperiod of the prior entraining cycles, the CREM gene is either subsensitive or supersensitive to induction. This differential responsiveness is controlled by the changing balance between positive (CREB) and negative (ICER) transcriptional regulators. Thus, the transcriptional response of the CREM gene is determined by the memory of past photoperiods. [References: 30]
机译：CREM基因（1-4）编码转录阻抑物ICER（3,5），与控制哺乳动物昼夜节律的分子机制有关（4-6）。 ICER在松果体中有节奏地表达，峰值水平出现在夜间（5）。 ICER水平通过视交叉上核（SCN）来调节。在黑暗中，通过从SCN向松果体输入肾上腺素来诱导转录，后者使用环状AMP和转录激活剂CREB激活ICER启动子。这种诱导是短暂的，因为ICER抑制了其自身的转录（3）。在这里，我们显示CREM基因对肾上腺素能刺激的反应由夜间长短决定，取决于先前的夹带周期的光周期，CREM基因要么是亚敏感的，要么是亚敏感的。对感应超敏感。这种不同的响应能力由正（CREB）和负（ICER）转录调节因子之间不断变化的平衡控制。因此，CREM基因的转录反应取决于过去光周期的记忆。 [参考：30]

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