TARGET-CELL-SPECIFIC CONCENTRATION OF A METABOTROPIC GLUTAMATE RECEPTOR IN THE PRESYNAPTIC ACTIVE ZONE

Shigemoto R.; Roberts JDB.; Ohishi H.; Nusser Z.; Kaneko T. Somogyi P.; Kulik A.

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TARGET-CELL-SPECIFIC CONCENTRATION OF A METABOTROPIC GLUTAMATE RECEPTOR IN THE PRESYNAPTIC ACTIVE ZONE

机译：突触活动区中代谢型谷氨酸受体的靶细胞特异性浓度

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THE probability of synaptic neurotransmitter release from nerve terminals is regulated by presynaptic receptors responding to transmitters released from the same nerve terminal or from terminals of other neurons. The release of glutamate, the major excitatory neurotransmitter, is suppressed by presynaptic autoreceptors(1-3). Here we show that a metabotropic glutamate receptor (mGluR7) in the rat hippocampus is restricted to the presynaptic grid, the site of synaptic vesicle fusion. Pyramidal cell terminals presynaptic to mGluR1 alpha-expressing interneurons have at least a ten-fold higher level of presynaptic mGluR7 than terminals making synapses with pyramidal cells and other types of interneuron. Distinct levels of mGluR7 are found at different synapses made by individual pyramidal axons or even single boutons. These results raise the possibility that presynaptic neurons could regulate the probability of transmitter release at individual synapses according to the postsynaptic target. [References: 31]

机译：突触前神经递质从神经末梢释放的可能性由突触前受体对从同一神经末梢或其他神经元末梢释放的递质作出反应来调节。谷氨酸（主要的兴奋性神经递质）的释放被突触前自体受体抑制（1-3）。在这里，我们显示大鼠海马中的代谢型谷氨酸受体（mGluR7）限于突触前网格，即突触小泡融合的位置。与表达mGluR1α的中间神经元突触前的金字塔形细胞末端，其突触前mGluR7的水平至少比与锥体细胞和其他类型的中间神经元进行突触的末端高十倍。在单独的锥体轴突或什至单个纽扣产生的不同突触中发现了不同水平的mGluR7。这些结果增加了突触前神经元可以根据突触后靶标调节个体突触中递质释放的可能性的可能性。 [参考：31]

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《Nature》 |1996年第6582期|p. 523-525|共3页
作者
Shigemoto R.; Roberts JDB.; Ohishi H.; Nusser Z.; Kaneko T. Somogyi P.; Kulik A.;
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作者单位

UNIV OXFORD MRC ANAT NEUROPHARMACOL UNIT DEPT PHARMACOL MANSFIELD RD OXFORD OX1 3TH ENGLAND;

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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
关键词
Synaptic transmission; Hippocampal-neurons; Calcium currents; Modulation;

机译：突触传递;海马神经元;钙电流;调节;

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1. Super-resolution imaging reveals the nanoscale organization of metabotropic glutamate receptors at presynaptic active zones [J] . Sana Siddig, Sarah Aufmkolk, S?ren Doose, Science Advances . 2020,第16期

机译：超分辨率成像显示出在突触前有源区的纳米级谷氨酸受体组织
2. Use-dependent increases in glutamate concentration activate presynaptic metabotropic glutamate receptors [J] . Scanziani M, Salin PA, Vogt KE, Nature . 1997,第6617期

机译：依赖于使用的谷氨酸浓度增加激活突触前代谢型谷氨酸受体。
3. Modulation of the intracellular calcium concentration in photoreceptor terminals by a presynaptic metabotropic glutamate receptor [J] . PETER KOULEN, RAINER KUHN, HEINZ WASSLE Proceedings of the National Academy of Sciences of the United States of America . 1999,第17期

机译：突触前代谢型谷氨酸受体对光感受器末端细胞内钙浓度的调节
4. Manifold learning visualization of Metabotropic Glutamate Receptors [C] . Martha-Ivon Cardenas, Alfredo Vellido, Jesus Giraldo International Conference of the Catalan Association for Artificial Intelligence . 2014

机译：代谢谷氨酸受体的歧管学习可视化
5. Presynaptic 5-HT receptors the lower cleft glutamate concentration and alter fictive locomotion in lamprey. [D] . Schwartz, Eric J. 2005

机译：突触前5-HT受体可降低七lamp鳗谷裂的谷氨酸浓度并改变其虚构运动。
6. Super-resolution imaging reveals the nanoscale organization of metabotropic glutamate receptors at presynaptic active zones [O] . Sana Siddig, Sarah Aufmkolk, Sören Doose, 2020

机译：超分辨率成像显示突触前活性区的代谢型谷氨酸受体的纳米级组织。
7. Metabotropic glutamate receptor 3 neuroprotection A. Berent-Spillson and J. W. Russell Received June 12, 2006; revised manuscript received October 3, 2006; accepted October 5, 2006. Address correspondence and reprint requests to James W. Russell, Department of Neurology, University of Maryland School of Medicine, 22 South Greene Street, Baltimore, MD 21201-1595, USA. E-mail: jruss@umich.edu Abbreviations used : APDC , 2 R ,4 R -4-aminopyrrolidine-2,4-dicarboxylate (specific metabotropic glutamate receptor 3 agonist) ; BSO , buthionine sulfoximine (GSH synthesis inhibitor) ; caspase , cysteine-requiring aspartate protease ; CysGly , cysteinylglycine (GSH degradation product) ; DAPI , 4′-6-diamidino-2-phenylindole ; DCF , dichlorodihydrofluorescein ; DCFDA , 5-(and 6)-chloromethyl-2′,7′-dichlorodihydrofluorescein diacetate, acetyl ester ; DHE , dihydroethidium ; DRG , dorsal root ganglion ; FCCP , carbonyl cyanide 4-(trifluoromethoxy)phenylhydrazone (electron transport uncoupler) ; GCP II/III , glutamate carboxypeptidase II/III ; GSH , glutathione ; GSH-EE , glutathione ethyl ester ; GST , glutathione-s-transferase ; H 2 O 2 , hydrogen peroxide ; HBSS , Hank’s balanced salt solution ; JC-1 , 5,5′,6,6′-tetrachloro-1,1′,3,3′-tetraethylbenzimidazolylcarbocyanine iodide ; MCB , monochlorobimane ; mGluR , metabotropic glutamate receptor ; NAAG , N -acetyl-aspartyl-glutamate ; PBS , phosphate-buffered saline ; PCD , programmed cell death ; Rh123 , rhodamine123 ; ROS , reactive oxygen species ; δψ μ , inner mitochondrial membrane potential . Metabotropic glutamate receptor 3 protects neurons from glucose-induced oxidative injury by increasing intracellular glutathione concentration [O] . Berent-Spillson Alison, Russell James W. 2007

机译：代谢型谷氨酸受体3神经保护a. Berent-spillson和J. W. Russell于2006年6月12日收到;修订稿于2006年10月3日收到; 2006年10月5日接受。美国马里兰州巴尔的摩市南格林街22号，马里兰大学医学院神经病学系James W. Russell的地址通信和重印申请。电子邮件：jruss@umich.edu使用的缩写：apDC，2R，4R-4-氨基吡咯烷-2,4-二羧酸酯（特异性代谢型谷氨酸受体3激动剂）; BsO，丁硫氨酸亚砜亚胺（GsH合成抑制剂）;半胱天冬酶，半胱氨酸需要的天冬氨酸蛋白酶; CysGly，半胱氨酰甘氨酸（GsH降解产物）; DapI，4'-6-二脒基-2-苯基吲哚; DCF，二氯二氢荧光素; DCFDa，5-（和6） - 氯甲基-2'，7'-二氯二氢荧光素二乙酸酯，乙酰酯; DHE，二氢乙锭; DRG，背根神经节; FCCp，羰基氰化物4-（三氟甲氧基）苯腙（电子传输解偶联剂）; GCp II / III，谷氨酸羧肽酶II / III;谷胱甘肽;谷胱甘肽; GsH-EE，谷胱甘肽乙酯; GsT，谷胱甘肽-s-转移酶; H 2 O 2，过氧化氢; HBss，Hank的平衡盐溶液; JC-1,5,5'，6,6'-四氯-1,1'，3,3'-四乙基苯并咪唑基酞菁碘化物; mCB，monochlorobimane; mGluR，代谢型谷氨酸受体; NaaG，N-乙酰基 - 天冬氨酰谷氨酸; pBs，磷酸盐缓冲盐水; pCD，程序性细胞死亡; Rh123，罗丹明123;活性氧，活性氧; δψμ，线粒体内膜电位。代谢型谷氨酸受体3通过增加细胞内谷胱甘肽浓度来保护神经元免受葡萄糖诱导的氧化损伤

TARGET-CELL-SPECIFIC CONCENTRATION OF A METABOTROPIC GLUTAMATE RECEPTOR IN THE PRESYNAPTIC ACTIVE ZONE

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