HIV-1 ENTRY INTO CD4(+) CELLS IS MEDIATED BY THE CHEMOKINE RECEPTOR CC-CKR-5

Dragic T.; Allaway GP.; Martin SR.; Huang YX.; Nagashima KA. Cayanan C.; Maddon PJ.; Koup RA.; Moore JP.; Paxton WA.; Litwin V.

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HIV-1 ENTRY INTO CD4(+) CELLS IS MEDIATED BY THE CHEMOKINE RECEPTOR CC-CKR-5

机译：HIV-1进入CD4（+）细胞的过程是由趋化因子受体CC-CKR-5介导的。

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The beta-chemokines MIP-1 alpha, MIP-1 beta and RANTES inhibit infection of CD4(+) T cells by primary, non-syncytium-inducing (NSI) HIV-1 strains at the virus entry stage, and also block env-mediated cell-cell membrane fusion. CD4(+) T cells from some HIV-1-exposed uninfected individuals cannot fuse with NSI HIV-1 strains and secrete high levels of beta-chemokines. Expression of the beta-chemokine receptor CC-CKR-5 in CD4(+), non-permissive human and non-human cells renders them susceptible to infection by NSI strains, and allows env-mediated membrane fusion. CC-CKR-5 is a second receptor for NSI primary viruses. [References: 29]

机译：β趋化因子MIP-1 alpha，MIP-1 beta和RANTES在病毒进入阶段抑制主要的，非合胞体诱导（NSI）HIV-1菌株对CD4（+）T细胞的感染，并阻断env-介导的细胞-细胞膜融合。来自一些未暴露HIV-1的个体的CD4（+）T细胞不能与NSI HIV-1菌株融合，并分泌高水平的β-趋化因子。 β趋化因子受体CC-CKR-5在CD4（+），非允许的人类和非人类细胞中的表达使其易于感染NSI菌株，并允许env介导的膜融合。 CC-CKR-5是NSI原发性病毒的第二种受体。 [参考：29]

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来源
《Nature》 |1996年第6584期|p. 667-673|共7页
作者
Dragic T.; Allaway GP.; Martin SR.; Huang YX.; Nagashima KA. Cayanan C.; Maddon PJ.; Koup RA.; Moore JP.; Paxton WA.; Litwin V.;
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作者单位

ROCKEFELLER UNIV AARON DIAMOND AIDS RES CTR NEW YORK NY 10016 USA;

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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
关键词
Immunodeficiency-virus; Functional expression; Cd4-mediated fusion;

机译：免疫缺陷病毒;功能表达;Cd4介导的融合;

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1. Mechanism for complement-mediated, antibody-dependent enhancement of human immunodeficiency virus type 1 infection in MT2 cells is enhanced entry through CD4, CD21, and CXCR4 chemokine receptors. [J] . Robinson WE Viral immunology . 2006,第3期

机译：补体介导的抗体依赖性增强MT2细胞中1型人类免疫缺陷病毒感染的机制是通过CD4，CD21和CXCR4趋化因子受体的进入增强。
2. Fetal exposure to HIV-1 alters chemokine receptor expression by CD4+T cells and increases susceptibility to HIV-1 [J] . Madeleine J. Bunders, John L. van Hamme, Machiel H. Jansen, Scientific reports. . 2014,第1期

机译：胎儿暴露于HIV-1会改变CD4 + T细胞的趋化因子受体表达，并增加对HIV-1的敏感性
3. Persistent resistance to HIV-1 infection in CD4 T cells from exposed uninfected Vietnamese individuals is mediated by entry and post-entry blocks [J] . Asier Sáez-Cirión, Pierre Versmisse, Lien X Truong, Retrovirology . 2006,第S1期

机译：进入和进入后的阻滞介导了越南未感染的越南个体对CD4 T细胞中HIV-1感染的持久抵抗力
4. Predicting the Co-receptors (CCR5 and CXCR4) of the Viruses R5, X4 and R5X4 that Cause AIDS (HIV-1) in Cells CD4 using The Bayes Classifier [C] . Francisco Javier Luna Rosas, Julio Cesar Martinez Romo, Carlos Alejandro de Luna Ortega, International Conference on Bioinformatics and Computational Biology . 2014

机译：预测病毒R5，X4和R5X4的共同受体（CCR5和CXCR4），其使用贝叶斯分类器导致细胞CD4中的艾滋病（HIV-1）
5. Expression of the interleukin-7 receptor alpha-chain is down regulated on CD4 T-cells by the HIV-1 Tat protien [D] . McLaughlin, Denny 2011

机译：HIV-1 Tat蛋白在CD4 T细胞上下调了白介素7受体α链的表达。
6. The leukotriene B4 receptor functions as a novel type of coreceptor mediating entry of primary HIV-1 isolates into CD4-positive cells [O] . Christer Owman, Alfredo Garzino-Demo, Fiorenza Cocchi, 1998

机译：白三烯B4受体作为一种介导新的HIV-1分离株进入CD4阳性细胞的新型共受体
7. The leukotriene B4 receptor functions as a novel type of coreceptor mediating entry of primary HIV-1 isolates into CD4-positive cells [O] . Owman, Christer, Garzino-Demo, Alfredo, Cocchi, Fiorenza, 1998

机译：白三烯B4受体作为一种介导新的HIV-1分离株进入CD4阳性细胞的新型共受体

HIV-1 ENTRY INTO CD4(+) CELLS IS MEDIATED BY THE CHEMOKINE RECEPTOR CC-CKR-5

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