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首页> 外文期刊>Nature >INFLUENCE OF DENDRITIC STRUCTURE ON FIRING PATTERN IN MODEL NEOCORTICAL NEURONS
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INFLUENCE OF DENDRITIC STRUCTURE ON FIRING PATTERN IN MODEL NEOCORTICAL NEURONS

机译：树突结构对模型新皮层神经元放电模式的影响

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NEOCORTICAL neurons display a wide range of dendritic morphologies, ranging from compact arborizations to highly elaborate branching patterns(1). In vitro electrical recordings from these neurons have revealed a correspondingly diverse range of intrinsic firing patterns, including non-adapting, adapting and bursting types(2,3). This heterogeneity of electrical responsivity has generally been attributed to variability in the types and densities of ionic channels. We show here, using compartmental models of reconstructed cortical neurons, that an entire spectrum of firing patterns can be reproduced in a set of neurons that share a common distribution of ion channels and differ only in their dendritic geometry. The essential behaviour of the model depends on partial electrical coupling of fast active conductances localized to the soma and axon and slow active currents located throughout the dendrites, and can be reproduced in a two-compartment model. The results suggest a causal relationship for the observed correlations between dendritic structure and firing properties(3-7) and emphasize the importance of active dendritic conductances in neuronal function(8-10). [References: 30]
机译：新皮质神经元显示出各种各样的树突形态，从紧凑的树状到高度复杂的分支模式（1）。这些神经元的体外电记录显示了相应的内在放电模式范围，包括非适应性，适应性和爆发性类型（2,3）。电响应性的这种异质性通常归因于离子通道类型和密度的可变性。我们在这里显示，使用重建的皮质神经元的隔室模型，可以在一组共享离子通道的共同分布且仅在其树突状几何形状不同的神经元中复制整个发射模式光谱。该模型的基本行为取决于局部分布在躯体和轴突上的快速有功电导的局部电耦合以及遍布整个树突的慢速有功电流，并且可以在两室模型中重现。结果表明，树突结构与放电特性之间存在因果关系（3-7），并强调了主动树突传导对神经元功能的重要性（8-10）。 [参考：30]

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