A P300/CBP-ASSOCIATED FACTOR THAT COMPETES WITH THE ADENOVIRAL ONCOPROTEIN E1A

Yang XJ.; Nishikawa J.; Howard BH.; Nakatani Y.; Ogryzko VV.

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A P300/CBP-ASSOCIATED FACTOR THAT COMPETES WITH THE ADENOVIRAL ONCOPROTEIN E1A

机译：与腺病毒癌蛋白E1A竞争的P300 / CBP相关因子

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The adenoviral oncoprotein E1A induces progression through the cell cycle by binding to the products of the p300/CBP and retinoblastoma gene families. A new cellular p300/CBP-associated factor (P/CAF) having intrinsic histone acetylase activity has been identified that competes with E1A. Exogenous expression of P/CAF in HeLa cells inhibits cell-cycle progression and counteracts the mitogenic activity of E1A. E1A disturbs the normal cellular interaction between p300/CBP and its associated histone acetylase. [References: 36]

机译：腺病毒癌蛋白E1A通过与p300 / CBP和视网膜母细胞瘤基因家族的产物结合，诱导整个细胞周期的进展。具有内在的组蛋白乙酰化酶活性的新型细胞p300 / CBP相关因子（P / CAF）已被鉴定出可与E1A竞争。 P / CAF在HeLa细胞中的外源表达抑制细胞周期进程并抵消E1A的促有丝分裂活性。 E1A干扰p300 / CBP及其相关的组蛋白乙酰化酶之间正常的细胞相互作用。 [参考：36]

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来源
《Nature》 |1996年第6589期|p. 319-324|共6页
作者
Yang XJ.; Nishikawa J.; Howard BH.; Nakatani Y.; Ogryzko VV.;
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作者单位

NICHHD LAB MOL GROWTH REGULAT NIH BETHESDA MD 20892 USA;

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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
关键词
Nuclear-protein cbp; Transcriptional adapters; Activation; Yeast; Creb; Dna; Nucleosome; Domains; Cells; P300;

机译：核蛋白cbp;转录衔接子;激活;酵母;Creb;Dna;核小体;域;细胞;P300;

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A P300/CBP-ASSOCIATED FACTOR THAT COMPETES WITH THE ADENOVIRAL ONCOPROTEIN E1A

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