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首页> 外文期刊>Nature >INDUCTION OF A SPECIFIC MUSCLE CELL TYPE BY A HEDGEHOG-LIKE PROTEIN IN ZEBRAFISH
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INDUCTION OF A SPECIFIC MUSCLE CELL TYPE BY A HEDGEHOG-LIKE PROTEIN IN ZEBRAFISH

机译：类似于刺猬的蛋白在斑马鱼中诱导特定的肌肉细胞类型

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摘要

THE notochord plays a central role in vertebrate development, acting as a signalling source that patterns the neural tube and somites(1-4). In in vitro assays, the secreted protein Sonic hedgehog mimics the inducing effects of notochord on both presomitic mesoderm and neural plate explants of amniote embryos, suggesting that both patterning activities of the notochord may be mediated by this protein in vivo(5-8). In zebrafish, however, mutants with disrupted notochord development lack a specific muscle cell type, the muscle pioneers, although they retain tile ability to induce neural differentiation, raising the possibility that neural tube and somite patterning may be mediated by distinct signals(9,10). Here we describe a new member of the hedgehog family, echidna hedgehog that is expressed exclusively in the notochord and has the ability to rescue the differentiation of muscle pioneer cells in mutants with no notochord, Moreover, we show that a combination of ectopic echidna hedgehog and sonic hedgehog expression induces supernumary muscle pioneers in wild-type embryos, suggesting that both signals act sequentially to pattern the developing somites. [References: 26]
机译：脊索在脊椎动物的发育中起着重要的作用，是神经管和体节模式的信号源（1-4）。在体外试验中，分泌的Sonic刺猬蛋白模仿了脊索对羊膜胚胎的早熟中胚层和神经板外植体的诱导作用，这表明脊索的两种构图活性可能都由该蛋白在体内介导（5-8）。然而，在斑马鱼中，脊索发育中断的突变体缺乏特定的肌肉细胞类型，即肌肉先驱者，尽管它们保留了诱导神经分化的能力，从而增加了神经管和体节模式可能由不同信号介导的可能性（9,10）。 ）。在这里，我们描述了刺猬家族的一个新成员，针ech刺猬，它仅在脊索中表达，并具有在没有脊索的突变体中挽救肌肉先驱细胞分化的能力。此外，我们证明了异位棘皮刺猬和声波刺猬的表达在野生型胚胎中诱导了多余的肌肉先驱，这表明这两个信号顺序起作用，以形成发育中的节节。 [参考：26]

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