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ANAPHASE AND CYTOKINESIS IN THE ABSENCE OF CHROMOSOMES

机译:染色体缺失时的苯甲酸和细胞分裂

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ANAPHASE and cytokinesis are key processes in the segregation of replicated chromosomes to the daughter cell: in anaphase, chromosomes move apart; in cytokinesis, a cleavage furrow forms midway between the separate chromosomes. Some evidence suggests that chromosomes may be involved both in controlling the timing of anaphase onset(1-3) and in dictating the position of the cleavage furrow(3). Other evidence indicates that the controlling mechanisms are intrinsic to the spindle and the cell(4-7). Here we test these possibilities in grasshopper spermatocytes by observing spindles and cells after removal of chromosomes. We found that both anaphase and cytokinesis occur independently of chromosomes: stage-specific changes occur at an appropriate time and in the correct way, despite the absence of chromosomes. This finding is particularly noteworthy because chromosomes have an important impact on spindle microtubule assembly(8,9) and the timing of anaphase onset(10) in these cells. [References: 17]
机译:ANAPHASE和胞质分裂是复制的染色体与子细胞分离的关键过程。在胞质分裂中,在分开的染色体之间的中间形成切割沟。一些证据表明,染色体可能参与控制后期发病的时间(1-3)和决定卵裂沟的位置(3)。其他证据表明控制机制是纺锤体和细胞固有的(4-7)。在这里,我们通过观察去除染色体后的纺锤体和细胞来测试蚱hopper精母细胞的这些可能性。我们发现后期和胞质分裂均独立于染色体发生:特定阶段的变化在适当的时间以正确的方式发生,尽管没有染色体。这一发现特别值得注意,因为染色体对这些细胞中的纺锤体微管装配(8,9)和后期发生的时机(10)有重要影响。 [参考:17]

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