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CONTROL OF CALCIUM OSCILLATIONS BY PHOSPHORYLATION OF METABOTROPIC GLUTAMATE RECEPTORS

机译：代谢型谷氨酸受体磷酸化控制钙的振荡

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STIMULATION of two metabotropic glutamate-receptor subtypes, mGluR1 and mGluR5, triggers the release of Ca2+ from intracellular stores through the inositol-(1,4,5)trisphosphate (InsP(3)) pathway(1-3). Here rye report that glutamate induces single-peaked intracellular Ca2+ mobilization in mGluR1 alpha-transfected cells but elicits Ca2+ oscillations in mGluR5a-transfected cells, The response patterns of the intracellular Ca2+ increase depend upon the identity of a single amino acid, aspartate (at position 854) or threonine (at position 840), located within the G-protein-interacting domains of mGluR1 alpha and mGluR5a, respectively, Pharmacological and peptide mapping analyses indicated that phosphorylation of the threonine residue at position 840 of mGluR5a by protein kinase C (PKC) is responsible for the generation of Ca2+ oscillations in mGluR5a-expressing cells, To our knowledge this is the first evidence that PKC phosphorylation of G-protein-coupled receptors is important in producing oscillations in intracellular Ca2+ signalling. [References: 29]
机译：对两种代谢型谷氨酸受体亚型mGluR1和mGluR5的刺激触发了Ca2 +通过肌醇-（1,4,5）三磷酸（InsP（3））途径从细胞内存储中释放（1-3）。黑麦在这里报告说，谷氨酸诱导mGluR1α转染的细胞中单峰细胞内Ca2 +动员，但在mGluR5a转染的细胞中引起Ca2 +振荡。细胞内Ca2 +的响应方式取决于单个氨基酸天冬氨酸（在位置）的身份854）或苏氨酸（位于840位）分别位于mGluR1 alpha和mGluR5a的G蛋白相互作用域内，药理和肽图分析表明mGluR5a 840位置的苏氨酸残基被蛋白激酶C（PKC）磷酸化）负责在表达mGluR5a的细胞中产生Ca2 +振荡。据我们所知，这是第一个证据，表明G蛋白偶联受体的PKC磷酸化在细胞内Ca2 +信号传导中产生振荡很重要。 [参考：29]

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