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首页> 外文期刊>Nature >A new group of conserved coactivators that increase the specificity of AP-1 transcription factors.
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A new group of conserved coactivators that increase the specificity of AP-1 transcription factors.

机译：一组新的保守共激活因子，可增加AP-1转录因子的特异性。

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摘要

The Jun proteins are nuclear proteins that combine with Fos proteins to form a gene-regulatory protein, AP-1. They have highly conserved DNA-binding and dimerization domains, resulting in almost identical sequence-recognition properties. Nevertheless, there are many indications that each Jun protein activates a distinct and only partially overlapping set of AP-1 target genes. Using the more variable activation domain of c-Jun as a bait, we identified a protein, JAB1, that interacts with c-Jun and JunD, but not with JunB or v-Jun. As a result, JAB1 selectively potentiates transactivation by only c-Jun or JunD. In vitro, JAB1 specifically stabilizes complexes of c-Jun or JunD with AP-1 sites and does not affect binding of either JunB or v-Jun. The amino-terminal half of JAB1 is very similar to the amino terminal region of Pad1 from fission yeast, which was identified genetically as a coactivator of a subset of AP-1 target genes. JAB1 and Pad1 are also functionally interchangeable. They define a new groupof coactivators that increase the specificity of target gene activation by AP-1 proteins.
机译：Jun蛋白是核蛋白，与Fos蛋白结合形成基因调节蛋白AP-1。它们具有高度保守的DNA结合和二聚结构域，从而导致几乎相同的序列识别特性。但是，有许多迹象表明，每种Jun蛋白都可以激活一组独特且仅部分重叠的AP-1靶基因。使用c-Jun的更多可变激活域作为诱饵，我们鉴定了与c-Jun和JunD相互作用但与JunB或v-Jun不相互作用的蛋白质JAB1。结果，JAB1仅通过c-Jun或JunD选择性地增强反式激活。在体外，JAB1特异性稳定c-Jun或JunD与AP-1位点的复合物，并且不影响JunB或v-Jun的结合。 JAB1的氨基末端一半与裂变酵母中Pad1的氨基末端区域非常相似，后者在基因上被确定为AP-1目标基因子集的共激活因子。 JAB1和Pad1在功能上也可以互换。他们定义了一组新的共激活因子，可增加AP-1蛋白激活靶基因的特异性。

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