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首页> 外文期刊>Nature >Requirement of the paraxis gene for somite formation and musculoskeletal patterning.
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Requirement of the paraxis gene for somite formation and musculoskeletal patterning.

机译：傍轴基因对体节形成和肌肉骨骼构图的要求。

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The segmental organization of the vertebrate embryo is first apparent when somites form in a rostrocaudal progression from the paraxial mesoderm adjacent to the neural tube. Newly formed somites appear as paired epithelial spheres that become patterned to form vertebrae, ribs, skeletal muscle and dermis. Paraxis is a basic helix-loop-helix transcription factor expressed in paraxial mesoderm and somites. Here we show that in mice homozygous for a paraxis null mutation, cells from the paraxial mesoderm are unable to form epithelia and so somite formation is disrupted. In the absence of normal somites, the axial skeleton and skeletal muscle form but are improperly patterned. Unexpectedly, however, we found that formation of epithelial somites was not required for segmentation of the embryo or for the establishment of somitic cell lineages. These results demonstrate that paraxis regulates somite morphogenesis, and that the function of somites is to pattern the axial skeleton and skeletal muscles.
机译：当体节从邻近神经管的近轴中胚层以杆状尾状逐渐形成时，脊椎动物胚胎的节段组织首先显现出来。新形成的节状体以成对的上皮球出现，并被图案化以形成椎骨，肋骨，骨骼肌和真皮。旁轴是在旁轴中胚层和躯体中表达的基本螺旋-环-螺旋转录因子。在这里，我们显示在纯合子的轴旁无效突变小鼠中，来自轴旁中胚层的细胞无法形成上皮细胞，因此破坏了体节的形成。在没有正常的节段的情况下，会形成轴向骨骼和骨骼肌，但是会形成不适当的图案。然而，出乎意料的是，我们发现不需要为胚胎的分割或建立体细胞谱系而形成上皮的体节。这些结果表明，轴心调节体节的形态发生，而体节的功能是构图轴向骨骼肌和骨骼肌。

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