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首页> 外文期刊>Nature >W/kit gene required for interstitial cells of Cajal and for intestinal pacemaker activity.
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W/kit gene required for interstitial cells of Cajal and for intestinal pacemaker activity.

机译：W / kit基因是Cajal的间质细胞和肠道起搏器活性所必需的。

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摘要

The pacemaker activity in the mammalian gut is responsible for generating anally propagating phasic contractions. The cellular basis for this intrinsic activity is unknown. The smooth muscle cells of the external muscle layers and the innervated cellular network of interstitial cells of Cajal, which is closely associated with the external muscle layers of the mammalian gut, have both been proposed to stimulate pacemaker activity. The interstitial cells of Cajal were identified in the last century but their developmental origin and function have remained unclear. Here we show that the interstitial cells of Cajal express the Kit receptor tyrosine kinase. Furthermore, mice with mutations in the dominant white spotting (W) locus, which have cellular defects in haematopoiesis, melanogenesis and gametogenesis as a result of mutations in the Kit gene, also lack the network of interstitial cells of Cajal associated with Auerbach's nerve plexus and intestinal pacemaker activity.
机译：哺乳动物肠道中的起搏器活动负责产生肛门传播的阶段性收缩。这种内在活性的细胞基础是未知的。已经提出了与哺乳动物肠的外部肌肉层紧密相关的外部肌肉层的平滑肌细胞和Cajal的间质细胞的神经支配的细胞网络都可以刺激起搏器活性。卡哈尔的间质细胞在上个世纪被发现，但是它们的发育起源和功能仍不清楚。在这里，我们显示Cajal的间质细胞表达Kit受体酪氨酸激酶。此外，具有显性白斑（W）基因座突变的小鼠由于Kit基因的突变而在造血，黑色素生成和配子发生中具有细胞缺陷，也缺乏与Auerbach神经丛相关的Cajal间质细胞网络。肠道起搏器活动。

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