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首页> 外文期刊>Nature >Protection and repair of the nigrostriatal dopaminergic system by GDNF in vivo.
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Protection and repair of the nigrostriatal dopaminergic system by GDNF in vivo.

机译：GDNF在体内保护和修复黑质纹状体多巴胺能系统。

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摘要

Glial-cell-line-derived neurotrophic factor (GDNF), a recently cloned new member of the transforming growth factor-beta superfamily, promotes survival of cultured fetal mesencephalic dopamine neurons and is expressed in the developing striatum. There have, however, been no reports about effects of GDNF in situ. We have used the dopaminergic neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), which produces parkinsonian symptoms in man, to determine whether GDNF might exert protective or regenerative effects in vivo in the adult nigrostriatal dopamine system in C57/B1 mice. GDNF injected over the substantia nigra or in striatum before MPTP potently protects the dopamine system, as shown by numbers of mesencephalic dopamine nerve cell bodies, dopamine nerve terminal densities and dopamine levels. When GDNF is given after MPTP, dopamine levels and fibre densities are significantly restored. In both cases, motor behaviour is increased above normal levels. We conclude that intracerebral GDNF administration exerts both protective and reparative effects on the nigrostriatal dopamine system, which may have implications for the development of new treatment strategies for Parkinson's disease.
机译：胶质细胞系衍生的神经营养因子（GDNF），最近克隆的转化生长因子-β超家族的新成员，促进了培养的胎儿中脑多巴胺神经元的存活，并在发育的纹状体中表达。但是，尚未有关于GDNF原位作用的报道。我们使用多巴胺能神经毒素1-甲基-4-苯基-1,2,3,6-四氢吡啶（MPTP）在人体内产生帕金森氏症，来确定GDNF是否可能在成年黑质纹状体体内发挥保护或再生作用C57 / B1小鼠的多巴胺系统。中脑多巴胺神经细胞体数量，多巴胺神经末梢密度和多巴胺水平显示，在MPTP之前，在黑质或纹状体上注射的GDNF可以有效保护多巴胺系统。在MPTP后给予GDNF时，多巴胺水平和纤维密度显着恢复。在这两种情况下，运动行为都会增加到正常水平以上。我们得出结论，脑内施用GDNF对黑质纹状体多巴胺系统既有保护作用又有修复作用，这可能对帕金森氏病新治疗策略的发展有影响。

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