• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Nature >Growth and differentiation in the Drosophila eye coordinated by hedgehog.
【24h】

Growth and differentiation in the Drosophila eye coordinated by hedgehog.

机译：果蝇眼中的生长和分化由刺猬协调。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Differentiation of the Drosophila retina is asynchronous: it starts at the posterior margin of the eye imaginal disc and progresses anteriorly over two days. During this time the disc continues to grow, increasing in size by approximately eightfold. An indentation in the epithelium, the morphogenetic furrow, marks the front edge of the differentiation wave. Anterior progression of the furrow is thought to be driven by signals emanating from differentiating photoreceptor cells in the posterior eye disc. A good candidate for such a signal is the product of the hedgehog (hh) gene; it is expressed, and presumably secreted, by differentiating photoreceptors and its function is required for continued furrow movement. Here we show that ectopic expression of hedgehog sets in motion ectopic furrows in the anterior eye disc. In addition to changes in cell shape, these ectopic furrows are associated with a tightly orchestrated series of events, including proliferation, cell cycle synchronization and pattern formation, that parallel normal furrow progression. We propose that the morphogenetic furrow coincides with a transient boundary that coordinates growth and differentiation of the eye disc, and that hedgehog is necessary and sufficient to propagate this boundary across the epithelium.
机译：果蝇视网膜的分化是异步的：它始于眼球间盘的后缘，并在两天内向前发展。在此期间，光盘继续增长，大小增加了大约八倍。上皮上的凹痕，即形态发生的沟，标志着分化波的前沿。沟的前部进展被认为是由后眼盘中分化的感光细胞发出的信号驱动的。刺猬（hh）基因的产物就是这种信号的一个很好的候选者。它是通过区分感光细胞表达的，并且可能是分泌的，并且它的功能是持续犁沟运动所必需的。在这里，我们显示了前眼盘运动异位沟中刺猬集的异位表达。除了细胞形状的变化外，这些异位犁沟还与一系列精心策划的事件相关，包括增殖，细胞周期同步和模式形成，与正常犁沟的发展平行。我们提出形态发生犁沟与瞬态边界相吻合，该边界协调了眼盘的生长和分化，并且刺猬是必要且足以在整个上皮中传播该边界的。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号