The G-protein-gated atrial K+ channel IKACh is a heteromultimer of two inwardly rectifying K(+)-channel proteins.

Krapivinsky G; Gordon EA; Wickman K; Velimirovic B; Krapivinsky L; Clapham DE

首页> 外文期刊>Nature >The G-protein-gated atrial K+ channel IKACh is a heteromultimer of two inwardly rectifying K(+)-channel proteins.

【24h】

The G-protein-gated atrial K+ channel IKACh is a heteromultimer of two inwardly rectifying K(+)-channel proteins.

机译：G蛋白门控性心房K +通道IKACh是两个向内整流的K（+）通道蛋白的异源多聚体。

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

Heart rate is slowed in part by acetylcholine-dependent activation of a cardiac potassium (K+) channel, IKACh. Activated muscarinic receptors stimulate IKACh via the G-protein beta gamma-subunits. It has been assumed that the inwardly rectifying K(+)-channel gene, GIRK1, alone encodes IKACh. It is now shown that IKACh is a heteromultimer of two distinct inwardly rectifying K(+)-channel subunits, GIRK1 and a newly cloned member of the family, CIR.

机译：心率部分受心脏钾（K +）通道IKACh的乙酰胆碱依赖性激活而减慢。激活的毒蕈碱受体通过G蛋白βγ亚基刺激IKACh。假定向内整流的K（+）通道基因GIRK1单独编码IKACh。现在表明，IKACh是两个不同的向内整流的K（+）通道亚基GIRK1和该家族的一个新克隆成员CIR的异源多聚体。

著录项

来源
《Nature》 |1995年第6518期|P.135-141|共7页
作者
Krapivinsky G; Gordon EA; Wickman K; Velimirovic B; Krapivinsky L; Clapham DE;
展开▼
作者单位

Department of Pharmacology, Mayo Foundation, Rochester, Minnesota 55905.;

展开▼
收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
关键词
Myocardium; Potassium Channels; CIR protein; GIRK1; Recombinant Proteins; 心肌; 钾通道;

机译：Myocardium;Potassium Channels;CIR protein;GIRK1;Recombinant Proteins;心肌;钾通道;

相似文献

外文文献
中文文献
专利

1. Evidence that neuronal G-protein-gated inwardly rectifying K+ channels are activated by G beta gamma subunits and function as heteromultimers. [J] . Kofuji P, Davidson N, Lester HA Proceedings of the National Academy of Sciences of the United States of America . 1995,第14期

机译：神经元G蛋白门控的内向整流性K +通道被G betaγ亚基激活并充当异源多聚体的证据。
2. Constitutively active G-protein-gated inwardly rectifying K+ channels in dendrites of hippocampal CA1 pyramidal neurons. [J] . Chen X, Johnston D The Journal of Neuroscience: The Official Journal of the Society for Neuroscience . 2005,第15期

机译：在海马CA1锥体神经元树突中的组成性活性G蛋白门控的内向整流K +通道。
3. The expression of G-protein-gated inwardly rectifying K+ channels GIRK1 and GIRK2 mRNAs in the supraoptic nucleus of the rat and possible role involved. [J] . Li JH, You ZD, Song CY, Neuroreport . 2001,第5期

机译：G蛋白门控的内向整流性K +通道GIRK1和GIRK2 mRNA在大鼠视上核中的表达及其可能的作用。
4. FLOW SENSITIVITY OF INWARDLY-RECTIFYING K{sup}+ CHANNELS IN HUMAN AOTIC ENDOTHELIUM [C] . Yun Fang, Victor Romanenko, Peter F. Davies, IASTED International Conference on Biomechanics . 2005

机译：在人体美食内皮中向内整流k {sup} +通道的流动敏感性
5. Development of Molecular Tools for the Investigation of G protein-gated Inwardly Rectifying Potassium (GIRK) Channels. [D] . Ramos-Hunter, Susan Joanne. 2017

机译：用于研究G蛋白门控的内向整流钾（GIRK）通道的分子工具的开发。
6. Evidence that neuronal G-protein-gated inwardly rectifying K+ channels are activated by G beta gamma subunits and function as heteromultimers. [O] . P Kofuji, N Davidson, H A Lester 1995

机译：神经元G蛋白门控的内向整流性K +通道被G betaγ亚基激活并充当异源多聚体的证据。
7. Evidence that neuronal G-protein-gated inwardly rectifying K+ channels are activated by G beta gamma subunits and function as heteromultimers. [O] . Kofuji, P, Davidson, N, Lester, H A 1995

机译：神经元G蛋白门控的内向整流性K +通道被G betaγ亚基激活并充当异源多聚体的证据。
8. Role of Mg(2+) in the Inactivation of Inwardly Rectifying K(+) Channels in AorticEndothelial Cells [R] . Elam, T. R., Lansman, J. B. 1995

机译：mg（2+）在主动脉内皮细胞内向整流K（+）通道失活中的作用

The G-protein-gated atrial K+ channel IKACh is a heteromultimer of two inwardly rectifying K(+)-channel proteins.

摘要

著录项

相似文献

相关主题

期刊订阅