Requirement for Lim1 in head-organizer function.

Shawlot W; Behringer RR

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Requirement for Lim1 in head-organizer function.

机译：整理器功能中对Lim1的要求。

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Lim1 is a homeobox gene expressed in the organizer region of mouse embryos. To investigate the role of Lim1 during embryogenesis, a targeted deletion of the Lim1 gene was generated in embryonic stem cells. Embryos homozygous for the null allele lacked anterior head structures but the remaining body axis developed normally. A partial secondary axis developed anteriorly in some mutant embryos. Lim1 is thus an essential regulator of the vertebrate head organizer.

机译：Lim1是在小鼠胚胎的组织区表达的同源盒基因。为了研究Lim1在胚胎发生过程中的作用，在胚胎干细胞中产生了Lim1基因的靶向缺失。无效等位基因的纯合子胚胎缺少前头部结构，但其余的体轴正常发育。在某些突变体胚胎中，部分次级轴向前方发展。因此，Lim1是脊椎动物头部组织者的重要调控因子。

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来源
《Nature》 |1995年第6521期|P.425-430|共6页
作者
Shawlot W; Behringer RR;
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作者单位

Department of Molecular Genetics, University of Texas M.D. Anderson Cancer Center, Houston 77030, USA.;

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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
关键词
Embryonic Induction; Fetal Development; Head; Homeodomain Proteins; Biological Markers; 胚胎诱导; 胎儿发育; 头部; 同源域蛋白质类;

机译：Embryonic Induction;Fetal Development;Head;Homeodomain Proteins;Biological Markers;胚胎诱导;胎儿发育;头部;同源域蛋白质类;

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3. Requirement of LIM domains for LIM1 function in mouse head development. [J] . Cheah SS, Kwan KM, Behringer RR Genesis: the journal of genetics and development . 2000,第1期

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Requirement for Lim1 in head-organizer function.

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