Polyadenylation of c-mos mRNA as a control point in Xenopus meiotic maturation.

Sheets MD; Wu M; Wickens M

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Polyadenylation of c-mos mRNA as a control point in Xenopus meiotic maturation.

机译：c-mos mRNA的聚腺苷酸化作为非洲爪蟾减数分裂成熟的一个控制点。

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c-mos protein, encoded by a proto-oncogene, is essential for the meiotic maturation of frog oocytes. Polyadenylation of c-mos messenger RNA is shown here to be a pivotal regulatory step in meiotic maturation. Maturation is prevented by selective amputation of polyadenylation signals from c-mos mRNA. Injection of a prosthetic RNA, which restores c-mos polyadenylation signals by base pairing to the amputated mRNA, rescues maturation and can stimulate translation in trans. Prosthetic RNAs may provide a general strategy by which to alter patterns of mRNA expression in vivo.

机译：c-mos蛋白由原癌基因编码，对于青蛙卵母细胞的减数分裂成熟至关重要。 c-mos信使RNA的聚腺苷酸在减数分裂成熟中是关键的调控步骤。通过选择性截肢来自c-mos mRNA的聚腺苷酸信号可防止成熟。义肢RNA的注射通过与截肢的mRNA碱基配对恢复c-mos聚腺苷酸化信号，可以拯救成熟并可以刺激反式翻译。修复的RNA可能提供改变体内mRNA表达模式的一般策略。

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来源
《Nature》 |1995年第6522期|P.511-516|共6页
作者
Sheets MD; Wu M; Wickens M;
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作者单位

Department of Biochemistry, College of Agriculture and Life Sciences, University of Wisconsin, Madison 53706, USA.;

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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
关键词
Meiosis; Poly A; Proto-Oncogene Proteins c-mos; RNA; Messenger; Oligonucleotides; Antisense; 减数分裂; 聚腺苷酸类; 原癌基因蛋白质C-MOS类; RNA; 信使;

机译：Meiosis;Poly A;Proto-Oncogene Proteins c-mos;RNA;Messenger;Oligonucleotides;Antisense;减数分裂;聚腺苷酸类;原癌基因蛋白质C-MOS类;RNA;信使;

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1. A gene regulation network controlled by Celf1 protein?￠????rbpj mRNA interaction in Xenopus somite segmentation A gene regulation network controlled by Celf1 protein?￠????rbpj mRNA interaction in Xenopus somite segmentation A gene regulation network controlled by Celf1 protein?￠????rbpj mRNA interaction in Xenopus somite segmentation [J] . Laurent Kodjabachian, Marie Cibois, Luc Paillard, Biology Open . 2013,第10期

机译：Celf1蛋白控制的基因调控网络，爪蟾体节中的rbpj mRNA相互作用Celf1蛋白控制的基因调控网络，爪蟾体部中的rbpj mRNA相互作用Celf1蛋白控制的基因调控网络非洲爪蟾体节段中的rbpj mRNA相互作用
2. The deadenylation conferred by the 3' untranslated region of a developmentally controlled mRNA in Xenopus embryos is switched to polyadenylation by deletion of a short sequence element. [J] . P Bouvet, F Omilli, Y Arlot-Bonnemains, Molecular and Cellular Biology . 1994,第3期

机译：非洲爪蟾胚胎中发育控制的mRNA的3'非翻译区所赋予的腺苷酸化通过短序列元件的缺失而转变为聚腺苷酸化。
3. Translational control of cyclin B1 mRNA during meiotic maturation: Coordinated repression and cytoplasmic polyadenylation [J] . Barkoff AF., Gray NK., Wickens N., Developmental biology . 2000,第1期

机译：减数分裂成熟期间细胞周期蛋白B1 mRNA的翻译控制：协同抑制和胞质多腺苷酸化。
4. A hybrid model for the prediction of mRNA polyadenylation signals [C] . Han Jiuqiang, Liu Ze, Zhong Dexing, Annual Conference of Japanese Society for Medical and Biological Engineering;Annual International Conference of the IEEE Engineering in Medicine and Biology Society . 2013

机译：用于预测mRNA多聚腺苷酸信号的混合模型
5. Bidirectional control of dendritic mRNA translation, glutamate receptor expression, and synapse structure by the CPEB-associated polyadenylation machinery. [D] . Swanger, Sharon A. 2012

机译：通过CPEB相关的聚腺苷酸化机制双向控制树突状mRNA的翻译，谷氨酸受体的表达和突触结构。
6. CPEB controls the cytoplasmic polyadenylation of cyclin Cdk2 and c-mos mRNAs and is necessary for oocyte maturation in Xenopus. [O] . B Stebbins-Boaz, L E Hake, J D Richter 1996

机译：CPEB控制细胞周期蛋白Cdk2和c-mos mRNA的胞质聚腺苷酸化对于非洲爪蟾的卵母细胞成熟是必需的。
7. The 3'-untranslated regions of c-mos and cyclin mRNAs stimulate translation by regulating cytoplasmic polyadenylation. [O] . M D Sheets, C A Fox, T Hunt, 1994

机译：C-MOS和Cyclin MRNA的3'-未翻译区域通过调节细胞质多腺苷酸化来刺激转换。

Polyadenylation of c-mos mRNA as a control point in Xenopus meiotic maturation.

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