Structural determinants of nuclear receptor assembly on DNA direct repeats.

Rastinejad F; Perlmann T; Evans RM; Sigler PB

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Structural determinants of nuclear receptor assembly on DNA direct repeats.

机译：DNA直接重复序列上核受体装配的结构决定因素。

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Nuclear receptor heterodimers recognize response elements composed of two direct repeats of the consensus sequence 5'-AGGTCA-3' separated by one to five base pairs. The 1.9 A crystal structure of the complex formed by the DNA-binding domains of the 9-cis retinoic acid receptor and thyroid hormone receptor bound to a thyroid-response element shows that the subunits interact through a DNA-supported interface involving the carboxy-terminal extension of the DNA-binding domain of the thyroid hormone receptor. The stereochemistry suggests a mechanism by which heterodimers recognize the inter-half-site spacing between direct repeats.

机译：核受体异二聚体识别应答元件，该应答元件由共有序列5'-AGGTCA-3'的两个直接重复组成，该重复重复由一到五个碱基对分隔。由结合于甲状腺反应元件的9-顺式视黄酸受体和甲状腺激素受体的DNA结合结构域形成的复合物的1.9 A晶体结构表明，这些亚基通过包含羧基末端的DNA支持的界面相互作用甲状腺激素受体的DNA结合结构域的延伸。立体化学提示异二聚体识别直接重复之间的半位点间间隔的机制。

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来源
《Nature》 |1995年第6528期|P.203-211|共9页
作者
Rastinejad F; Perlmann T; Evans RM; Sigler PB;
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作者单位

Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06510, USA.;

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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
关键词
DNA; DNA-Binding Proteins; Receptors; Retinoic Acid; Receptors; Thyroid Hormone; DNA结合蛋白质类; 受体; 维甲酸; 受体; 甲状腺激素; 重复序列; 核酸;

机译：DNA;DNA-Binding Proteins;Receptors;Retinoic Acid;Receptors;Thyroid Hormone;DNA结合蛋白质类;受体;维甲酸;受体;甲状腺激素;重复序列;核酸;

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1. Molecular determinants for nuclear receptors selectivity: Chemometric analysis, dockings and site-directed mutagenesis of dual peroxisome proliferator-activated receptors α/γ agonists [J] . CarrieriA., GiudiciM., ParenteM., European Journal of Medicinal Chemistry: Chimie Therapeutique . 2013,第Null期

机译：核受体选择性的分子决定因素：双重过氧化物酶体增殖物激活受体α/γ激动剂的化学计量分析，对接和定点诱变
2. Determinants of CoRNR-Dependent Repression Complex Assembly on Nuclear Hormone Receptors [J] . Xiao Hu, Yun Li, Mitchell A. Lazar Molecular and Cellular Biology . 2001,第5期

机译：核激素受体的依赖CoRNR的阻遏复杂大会的决定因素。
3. Ligand Recognition by Drug-Activated Nuclear Receptors PXR and CAR: Structural, Site-Directed Mutagenesis and Molecular Modeling Studies [J] . Antti Poso Paavo Honkakoski Mini-Reviews in Medicinal Chemistry . 2006,第8期

机译：药物激活核受体PXR和CAR的配体识别：结构，定点诱变和分子建模研究。
4. Strategies for Bioassay-Directed UPLC-MS Discovery of Ligands for Nuclear Receptors using Multiplexed CID and Mass Defect Filtering. [C] . Michael C. Stagliano, Joshua G. DeKeyser, Curtis J. Omiecinski, ASMS Conference on Mass Spectrometry and Allied Topics . 2008

机译：使用多路复用CID和质量缺陷滤波的核受体的配体的生物测定的UPLC-MS发现的策略。
5. Determinants of the DNA Binding and Gene Regulatory Specificity for Type II Nuclear Receptor Signaling [D] . Penvose, Ashley. 2020

机译：II型核受体信号传导DNA结合和基因调节特异性的决定因素
6. The dimerization interfaces formed between the DNA binding domains of RXR RAR and TR determine the binding specificity and polarity of the full-length receptors to direct repeats. [O] . C Zechel, X Q Shen, J Y Chen, 1994

机译：RXRRAR和TR的DNA结合结构域之间形成的二聚化界面决定了全长受体指导直接重复的结合特异性和极性。
7. The dimerization interfaces formed between the DNA binding domains of RXR, RAR and TR determine the binding specificity and polarity of the full-length receptors to direct repeats. [O] . C. Zechel, X.Q. Shen, J.Y. Chen, 1994

机译：在RXR，RAR和Tr的DNA结合结构域之间形成的二聚界面确定全长受体的结合特异性和极性以指导重复。
8. Multi-Domain Assembly of Nuclear Estrogen Receptors: Structural Insights into ER-Positive Breast Cancer Therapeutics. [R] . G. Greene 2013

机译：核雌激素受体的多域组装：ER阳性乳腺癌治疗的结构见解。

Structural determinants of nuclear receptor assembly on DNA direct repeats.

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