Herpes simplex virus turns off the TAP to evade host immunity.

Hill A; Jugovic P; York I; Russ G; Bennink J; Yewdell J; Ploegh H; Johnson D

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Herpes simplex virus turns off the TAP to evade host immunity.

机译：单纯疱疹病毒会关闭TAP，以逃避宿主的免疫力。

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Many viruses have evolved mechanisms to avoid detection by the host immune system. Herpes simplex virus (HSV) expresses an immediate early protein, ICP47, which blocks presentation of viral peptides to MHC class I-restricted cells. The properties of the newly synthesized class I molecules in HSV-infected cells resemble those of cell lines deficient in the transporter associated with antigen processing (TAP) in that class I molecules are retained in the endoplasmic reticulum, and the heavy chain and beta 2-microglobulin subunits dissociate in detergent extracts but the complex can be stabilized by peptides. We show here that ICP47 binds to TAP and prevents peptide translocation into the endoplasmic reticulum.

机译：许多病毒已经进化出避免宿主免疫系统检测的机制。单纯疱疹病毒（HSV）表达一种即时早期蛋白ICP47，该蛋白阻止病毒肽向MHC I类限制性细胞的呈递。 HSV感染细胞中新合成的I类分子的特性类似于缺乏与抗原加工（TAP）相关的转运蛋白的细胞系的特性，因为I类分子保留在内质网中，并且重链和β2-微球蛋白亚基在去污剂提取物中解离，但复合物可通过肽稳定。我们在这里显示ICP47与TAP结合并防止肽易位进入内质网。

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来源
《Nature》 |1995年第6530期|P.411-415|共5页
作者
Hill A; Jugovic P; York I; Russ G; Bennink J; Yewdell J; Ploegh H; Johnson D;
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作者单位

Department of Biology, Massachusetts Institute of Technology, Cambridge 02139-4307, USA.;

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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
关键词
ATP Binding Cassette Transporters metabolism; Immediate-Early Proteins; Simplexvirus; 即早蛋白质类; 单纯病毒属;

机译：ATP Binding Cassette Transporters metabolism;Immediate-Early Proteins;Simplexvirus;即早蛋白质类;单纯病毒属;

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1. Host responses to herpes simplex virus and herpes simplex virus vectors [J] . Veijo Hukkanen, Henrik Paavilainen, Riikka K Mattila Future Virology . 2010,第4期

机译：宿主对单纯疱疹病毒和单纯疱疹病毒载体的反应
2. Modulation of human {beta}-defensin-1 (hBD-1) in plasmacytoid dendritic cells (PDC), monocytes, and epithelial cells by influenza virus, Herpes simplex virus, and Sendai virus and its possible role in innate immunity. [J] . Ryan LK, Dai J, Yin Z, Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society . 2011,第2期

机译：流感病毒，单纯疱疹病毒和仙台病毒对浆细胞样树突状细胞（PDC），单核细胞和上皮细胞中人β-防御素1（hBD-1）的调节及其在先天免疫中的可能作用。
3. Mapping of a herpes simplex virus type 2-encoded function that affects the susceptibility of herpes simplex virus-infected target cells to lysis by herpes simplex virus-specific cytotoxic T lymphocytes. [J] . V C Carter, S R Jennings, P L Rice, Journal of Virology . 1984,第3期

机译：疱疹病毒型2编码功能的映射，影响单纯疱疹病毒感染的靶细胞的易感性通过疱疹病毒特异性细胞毒性T淋巴细胞裂解。
4. Antiviral Activity of Cisplatin Derivatives of Methotrexate Against Vaccinia Virus, Varicella Zoster Virus (VZV), Reovirus ST3, and Herpes Simplex Virus (HSV-1) [C] . Michael R. Roner, Charles E. Carraher Jr., Salima Dhanji PMSE Symposia . 2005

机译：甲氨蝶呤对痘苗病毒，植物疱疹病毒（VZV），reoVirus ST3和单纯疱疹病毒（HSV-1）的抗病毒活性
5. Beyond host shut-off: Identification of a novel role for the virion host shut-off (vhs) protein of herpes simplex virus type 1 (HSV-1) in immune evasion [D] . Cotter, Christopher 2011

机译：超越宿主关闭：鉴定单纯疱疹病毒1型（HSV-1）的病毒体宿主关闭（vhs）蛋白在免疫逃逸中的新作用
6. Virion component of herpes simplex virus type 1 KOS interferes with early shutoff of host protein synthesis induced by herpes simplex virus type 2 186. [O] . T M Hill, J R Sadler, J L Betz 1985

机译：1型单纯疱疹病毒的病毒颗粒成分干扰2186型单纯疱疹病毒诱导的宿主蛋白合成的早期关闭。
7. Mapping of a herpes simplex virus type 2-encoded function that affects the susceptibility of herpes simplex virus-infected target cells to lysis by herpes simplex virus-specific cytotoxic T lymphocytes [O] . V C Carter, S R Jennings, P L Rice, 1984

机译：疱疹病毒型2编码功能的映射，影响疱疹病毒感染的靶细胞对单纯疱疹病毒特异性细胞毒性T淋巴细胞裂解疱疹病毒感染靶细胞的敏感性

Herpes simplex virus turns off the TAP to evade host immunity.

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