Crystal structure of the ligand-binding domain of the human nuclear receptor RXR-alpha.

Bourguet W; Ruff M; Chambon P; Gronemeyer H; Moras D

首页> 外文期刊>Nature >Crystal structure of the ligand-binding domain of the human nuclear receptor RXR-alpha.

【24h】

Crystal structure of the ligand-binding domain of the human nuclear receptor RXR-alpha.

机译：人核受体RXR-alpha的配体结合结构域的晶体结构。

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

The crystal structure of the human retinoid-X receptor RXR-alpha ligand-binding domain reveals a previously undiscovered fold of an antiparallel alpha-helical sandwich, packed as dimeric units. Two helices and one loop form the homodimerization surface, and hydrophobic heptad repeats participate in stabilizing the fold. The existence of a ligand-binding pocket is proposed that would allow 9-cis retinoic acid to interact with different functional modules, including the AF-2 activating domain. Several lines of evidence indicate that the overall structure is a prototype fold of ligand-binding domains of nuclear receptors.

机译：人类视黄醇X受体RXR-α配体结合域的晶体结构揭示了反平行的α-螺旋夹心的先前未发现的折叠，以二聚体单位包装。两个螺旋和一个环形成均二聚化表面，并且疏水七肽重复序列参与稳定折叠。提出了配体结合袋的存在，其将允许9-顺式视黄酸与包括AF-2活化域的不同功能模块相互作用。几条证据表明，总体结构是核受体配体结合域的原型折叠。

著录项

来源
《Nature》 |1995年第6530期|P.377-382|共6页
作者
Bourguet W; Ruff M; Chambon P; Gronemeyer H; Moras D;
展开▼
作者单位

Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS/INSERM/ULP/College de France, Illkirch, CU de Strasbourg.;

展开▼
收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
关键词
Receptors; Retinoic Acid; Transcription Factors; AF-2-protein; Biopolymers; 受体; 维甲酸; 转录因子;

机译：Receptors;Retinoic Acid;Transcription Factors;AF-2-protein;Biopolymers;受体;维甲酸;转录因子;

相似文献

外文文献
中文文献
专利

1. A revisited version of the apo structure of the ligand-binding domain of the human nuclear receptor retinoic X receptor a [J] . Jér?me Eberhardt, Alastair G. McEwen, William Bourguet, Acta crystallographica. Section F, Structural biology communications . 2019,第2期

机译：检测人体核受体视网膜X受体A的配体结合结构域的APO结构的重新发布版本
2. Comparison of crystal structures of human androgen receptor ligand-binding domain complexed with various agonists reveals molecular determinants responsible for binding affinity. [J] . Pereira de Jesus Tran K, Cote PL, Cantin L, Protein Science: A Publication of the Protein Society . 2006,第5期

机译：人雄激素受体配体结合域与各种激动剂复合的晶体结构的比较揭示了负责结合亲和力的分子决定簇。
3. Over-expression and purification of isotopically labeled recombinant ligand-binding domain of orphan nuclear receptor human B1-binding factor/human liver receptor homologue 1 for NMR studies [J] . Chen X, Tong XT, Xie YH, Protein Expression and Purification . 2006,第1期

机译：NMR研究的孤核受体人类B1结合因子/人类肝脏受体同源物1的同位素标记重组配体结合结构域的过表达和纯化
4. The Three-Dimensional Structure of the N-Terminal Domain of Corticotropin-Releasing Factor Receptors:Sushi Domains and the B1 Family of G Protein—Coupled Receptors [C] . MARILYN H. PERRIN, CHRISTY R. R. GRACE, ROLAND RIEK, International Symposium on VIP, PACAP, and Related Peptides . 2006

机译：皮质激素释放因子受体N-末端结构域的三维结构：寿司结构域和B1蛋白偶联受体的B1系列
5. Crystal structure of the human estrogen receptor alpha ligand-binding domain: Estradiol complex [D] . Tanenbaum, David Michael. 1998

机译：人雌激素受体α配体结合域的晶体结构：雌二醇复合物
6. Comparison of crystal structures of human androgen receptor ligand-binding domain complexed with various agonists reveals molecular determinants responsible for binding affinity [O] . Karine Pereira de Jésus-Tran, Pierre-Luc Côté, Line Cantin, 2006

机译：与各种激动剂复合的人类雄激素受体配体结合结构域的晶体结构比较揭示了负责结合亲和力的分子决定簇
7. Crystal Structure of the T877A Human Androgen Receptor Ligand-binding Domain Complexed to Cyproterone Acetate Provides Insight for Ligand-induced Conformational Changes and Structure-based Drug Design [O] . Casey E. Bohl, Zengru Wu, Duane D. Miller, 2007

机译：T877A人雄激素受体配体结合域络合到硫代丙烯酸酯的T877A人雄激素受体配体结合结构域提供了对配体诱导的构象变化和基于结构的药物设计的洞察力

Crystal structure of the ligand-binding domain of the human nuclear receptor RXR-alpha.

摘要

著录项

相似文献

相关主题

期刊订阅