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首页> 外文期刊>Nature >Phantom-limb pain as a perceptual correlate of cortical reorganization following arm amputation.
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Phantom-limb pain as a perceptual correlate of cortical reorganization following arm amputation.

机译：幻肢疼痛是手臂截肢后皮层重组的知觉相关因素。

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摘要

Although phantom-limb pain is a frequent consequence of the amputation of an extremity, little is known about its origin. On the basis of the demonstration of substantial plasticity of the somatosensory cortex after amputation or somatosensory deafferentation in adult monkeys, it has been suggested that cortical reorganization could account for some non-painful phantom-limb phenomena in amputees and that cortical reorganization has an adaptive (that is, pain-preventing) function. Theoretical and empirical work on chronic back pain has revealed a positive relationship between the amount of cortical alteration and the magnitude of pain, so we predicted that cortical reorganization and phantom-limb pain should be positively related. Using non-invasive neuromagnetic imaging techniques to determine cortical reorganization in humans, we report a very strong direct relationship (r = 0.93) between the amount of cortical reorganization and the magnitude of phantom limb pain (but not non-painful phantom phenomena) experienced after arm amputation. These data indicate that phantom-limb pain is related to, and may be a consequence of, plastic changes in primary somatosensory cortex.
机译：尽管幻肢疼痛是肢体截肢的常见后果，但对其起源知之甚少。根据成年猴子截肢或体感脱除果皮后体感皮层可塑性显着的事实，有人提出皮层重组可以解释截肢者的一些非痛性幻肢现象，并且皮层重组具有适应性（即预防疼痛）功能。关于慢性背痛的理论和经验研究表明，皮质改变量与疼痛程度之间存在正相关关系，因此我们预测皮质重组与幻肢痛应呈正相关。使用无创神经磁成像技术确定人类的皮质重组，我们报告了皮层重组的数量与幻肢疼痛程度（而非非疼痛幻影现象）之间存在非常密切的直接关系（r = 0.93）手臂截肢。这些数据表明幻肢疼痛与原代体感皮层的塑性变化有关，也可能是这种变化的结果。

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