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首页> 外文期刊>Nature >A conserved system for dorsal-ventral patterning in insects and vertebrates involving sog and chordin.
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A conserved system for dorsal-ventral patterning in insects and vertebrates involving sog and chordin.

机译：一个保守的系统，用于在昆虫和脊椎动物中涉及sog和chordin的背腹模式。

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摘要

Dorsal-ventral patterning within the ectoderm of the Drosophila embryo requires seven zygotic genes, including short gastrulation (sog). Here we demonstrate that sog, which is expressed in the ventrolateral region of the embryo that gives rise to the nerve cord, is functionally homologous to the chordin gene of Xenopus, which is expressed in the dorsal blastopore lip of the embryo and in dorsal mesoderm, in particular the notochord. We show by injections of messenger RNA that both sog and chordin can promote ventral development in Drosophila, and that sog, like chordin, can promote dorsal development in Xenopus. In Drosophila, sog antagonizes the dorsalizing effects of decapentaplegic (dpp), a member of the transforming growth factor-beta family. One of the dpp homologues in vertebrates, bmp-4, is expressed ventrally in Xenopus and promotes ventral development. We show that dpp can promote ventral fates in Xenopus, and that injection of sog mRNA counteracts the ventralizing effects of dpp. These results suggest the molecular conservation of dorsoventral patterning mechanisms during evolution.
机译：果蝇胚胎的外胚层中的背腹模式需要七个合子基因，包括短促胃泌性（sog）。在这里，我们证明了在胚胎的腹外侧区域表达的sog（其产生神经线）在功能上与非洲爪蟾的chordin基因同源，该基因在胚胎的背胚孔唇和中胚层中表达，特别是脊索。通过注射信使RNA，我们发现sog和chordin均可促进果蝇的腹侧发育，而sog与chordin一样可促进非洲爪蟾的背侧发育。在果蝇中，sog拮抗十倍体瘫痪（dpp）（转化生长因子-β家族的成员）的背痛作用。脊椎动物中的一种dpp同源物bmp-4在非洲爪蟾腹侧表达并促进腹侧发育。我们表明dpp可以促进非洲爪蟾的腹侧命运，而sog mRNA的注入抵消了dpp的腹侧作用。这些结果表明在进化过程中背腹模式机制的分子守恒。

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