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首页> 外文期刊>Nature >Epithelial immaturity and multiorgan failure in mice lacking epidermal growth factor receptor.
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Epithelial immaturity and multiorgan failure in mice lacking epidermal growth factor receptor.

机译：缺乏表皮生长因子受体的小鼠的上皮不成熟和多器官功能衰竭。

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摘要

Since the discovery that epidermal growth factor (EGF) can accelerate opening of the eyelids, the EGF receptor (EGF-R) has been extensively studied and is now considered to be a prototype tyrosine kinase receptor. Binding of EGF or of transforming growth factor-alpha (TGF-alpha) or other related factors activates the receptor and induces cell proliferation and differentiation. Although it is not found on haematopoietic cells, the EGF-R is widely expressed in mammals and has been implicated in various stages of embryonic development. Here we investigate the developmental and physiological roles of this receptor and its ligands by inactivating the gene encoding EGF-R. We find that EGF-R-/- mice survive for up to 8 days after birth and suffer from impaired epithelial development in several organs, including skin, lung and gastrointestinal tract.
机译：自从发现表皮生长因子（EGF）可以加速眼睑张开以来，对EGF受体（EGF-R）进行了广泛研究，现在被认为是酪氨酸激酶受体的原型。 EGF或转化生长因子-α（TGF-α）或其他相关因子的结合激活受体并诱导细胞增殖和分化。尽管在造血细胞上未发现，但EGF-R在哺乳动物中广泛表达，并与胚胎发育的各个阶段有关。在这里，我们通过失活编码EGF-R的基因来研究该受体及其配体的发育和生理作用。我们发现EGF-R-/-小鼠出生后可存活长达8天，并在包括皮肤，肺和胃肠道在内的多个器官中遭受上皮发育受损。

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