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首页> 外文期刊>Nature >Autocrine mitogenic activity of pheromones produced by the protozoan ciliate Euplotes raikovi.
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Autocrine mitogenic activity of pheromones produced by the protozoan ciliate Euplotes raikovi.

机译：原生动物纤毛虫Euplotes raikovi产生的信息素的自分泌促有丝分裂活性。

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Diffusible polypeptide pheromones (formerly referred to as mating-type factors, sex factors or gamones), which distinguish otherwise morphologically identical vegetative cell (mating) types from one another, are produced by some species of ciliates. Their most striking effect can be observed by exposing cells of one type to a pheromone secreted by another co-specific cell type. In the presence of this 'non-self' signal, these cells interrupt their vegetative life to unite temporarily in mating pairs. Thus ciliate pheromones have traditionally been associated only with mating induction. However, the identification of autocrine pheromone receptors suggests a broader role, which is supported by the hypothesis that ciliates evolved their mating-type mechanism for pursuing self-recognition. We now report studies, in the cosmopolitan marine sand-dwelling protozoan ciliate Euplotes raikovi, demonstrating that these molecules promote the vegetative reproduction (mitogenic proliferation or growth) of the same cells from which they originate. As, understandably, such autocrine pheromone activity is primary to that of targeting and inducing a foreign cell to mate (paracrine functions), this finding provides an example of how the original function of a molecule can be obscured during evolution by the acquisition of a new one.
机译：某些纤毛虫产生了可扩散的多肽信息素（以前称为交配型因子，性别因子或配子），它们在形态学上彼此区别，而营养细胞（交配）类型彼此不同。通过将一种类型的细胞暴露于另一种共特异性细胞类型分泌的信息素中，可以观察到它们最惊人的作用。在存在这种“非自我”信号的情况下，这些细胞会中断其营养生命，暂时配对。因此，纤毛信息素传统上仅与交配诱导相关。但是，自分泌信息素受体的鉴定显示了更广泛的作用，这一点得到了纤毛虫进化其追求自我识别的交配型机制的假设的支持。现在，我们在国际化的海洋沙栖原生动物纤毛虫Euplotes raikovi中进行了报道，证明这些分子促进了它们起源的相同细胞的营养繁殖（有丝分裂增殖或生长）。可以理解，因为这种自分泌信息素活性是靶向和诱导外来细胞交配（旁分泌功能）的主要活性，因此这一发现提供了一个例子，说明在进化过程中如何通过收购新分子来掩盖分子的原始功能。一。

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