• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Nature >A metalloprotease-disintegrin participating in myoblast fusion.
【24h】

A metalloprotease-disintegrin participating in myoblast fusion.

机译：金属蛋白酶-解整合素参与成肌细胞融合。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Skeletal muscle development involves the formation of multi-nucleated myotubes. This is thought to proceed by the induction of differentiation (acquisition of fusion competence) of myoblast cells, their aggregation, and union of their plasma membranes. Various membrane proteins including N- and M-cadherins, N- and V-CAMs and integrins participate in myotube formation, but the molecular mechanisms of muscle cell fusion are poorly understood. Here we report the identification of three new, myoblast-expressed gene products, meltrin-alpha, beta and gamma, with homology to both viper haemorrhagic factors and fertilin (PH-30), a membrane protein involved in egg-sperm fusion. Meltrin-alpha, a member of the metalloproteinase/disintegrin protein family, appears to be required for myotube formation. Involvement of a fertilin-related protein in myogenesis suggests that there are common mechanisms in gamete and myoblast fusion.
机译：骨骼肌发育涉及多核肌管的形成。据认为，这是通过诱导成肌细胞分化，融合能力和质膜结合而进行的。各种膜蛋白包括N-和M-钙粘着蛋白，N-和V-CAM和整联蛋白参与肌管的形成，但对肌肉细胞融合的分子机制了解甚少。在这里，我们报告鉴定了三种新的成肌细胞表达的基因产物，即融合蛋白-α，β和γ，与vi蛇出血因子和铁蛋白（PH-30）（参与卵子-精子融合的膜蛋白）具有同源性。 Meltrin-α，金属蛋白酶/解整合蛋白蛋白家族的成员，似乎是肌管形成所必需的。铁蛋白相关蛋白参与肌生成过程表明配子和成肌细胞融合存在共同的机制。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号