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SUPPRESSION OF PSYCHOACTIVE EFFECTS OF COCAINE BY ACTIVE IMMUNIZATION

机译：主动免疫抑制可卡因的心理作用

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COCAINE is a powerfully addictive substance and new strategies are needed to treat its abuse. Generating an active immunization(1,2) to cocaine offers a means of blocking the actions of the drug by preventing it from entering the central nervous system, and should have fewer side effects than treatments based on manipulation of central neurotransmitter function. The design and preparation of a cocaine immunogen requires special regard for the stability of cocaine both free and as a haptenic determinant. Immunochemistry and a well defined behavioural model were brought together to address the problem of inactivation of the psychostimulant actions of cocaine. We report here that active immunization with a new, stable cocaine conjugate suppressed locomotor activity and stereotyped behaviour in rats induced by cocaine but not by amphetamine, Moreover, following acute injection of cocaine, levels of cocaine in the striatum and cerebellum of the immunized animals were lower than those of control animals, These results suggest that immunopharmacotherapy may be a promising means by which to explore new treatments for cocaine abuse.
机译：可卡因是一种强力上瘾的物质，需要新的策略来治疗其滥用。对可卡因进行主动免疫（1,2）提供了一种通过阻止药物进入中枢神经系统来阻止其作用的手段，并且其副作用要少于基于中枢神经递质功能的治疗方法。可卡因免疫原的设计和制备需要特别考虑可卡因游离和半抗原决定簇的稳定性。免疫化学和明确定义的行为模型结合在一起，以解决可卡因的精神刺激作用失活的问题。我们在这里报告，用新的，稳定的可卡因共轭物进行的主动免疫抑制了可卡因而不是苯丙胺诱导的大鼠的自发活动和刻板行为，而且，在急性注射可卡因后，被免疫动物的纹状体和小脑中的可卡因水平这些结果表明，免疫药物疗法可能是探索可卡因滥用新疗法的一种有前途的手段。

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