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首页> 外文期刊>NeuroRehabilitation >The role of citicholine in neuropsychological training after traumatic brain injury
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The role of citicholine in neuropsychological training after traumatic brain injury

机译：胞磷胆碱在颅脑外伤后神经心理训练中的作用

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{it Objective:} To report new strategies in the treatment of persistent memory deficits following traumatic brain injury (TBI) using a combination of pharmacology and neuropsychological training. {it Study design:} Two studies were carried out. The first study measured the regional cerebral blood flow (rCBF) of seven Patients with TBI with very severe memory deficits, once while resting and once one hour after the administration of citicholine (CDPc). In the second study, two groups of five patients of the same characteristics underwent an ecological neuropsychological memory rehabilitation program; during which time, one group was administered a placebo (Group A), and the other received CDPc (1~g/d v.o.) (Group B). {it Results:} The results of Experiment 1 showed a hypoperfusion of the inferior left temporal cerebral blood flow during rest state while an induced normalization was observed after administration of the drug. Results of Experiment 2 showed no improvements in Group A's neuropsychological functions, while memory, learning processes and verbal fluency of Group B improved significantly after treatment. {it Conclusions:} CDP-choline seems to be a drug with special affinity for cerebral areas associated with memory acting just where needed, normalizing blood flow in the hypoperfused left temporo-basal region, and making neuropsychological training effective. In general, data suggests that cognitive rehabilitation would follow the principle of first restoring and maintaining cerebral blood flow in the lesional site and then exercising function. In this study on memory rehabilitation, memory recuperation was made possible by first normalizing blood flow at the lesional site and at the same time applying neuropsychological training.
机译：{it目标：}报告结合药理学和神经心理学培训，用于治疗颅脑外伤（TBI）后持续性记忆缺陷的新策略。 {it研究设计：}进行了两项研究。第一项研究测量了七名患有非常严重记忆缺陷的TBI患者的局部脑血流量（rCBF），一次是在休息时，另一次是在给予胆碱（CDPc）后一小时。在第二项研究中，两组具有相同特征的五名患者接受了生态神经心理记忆康复计划；在此期间，一组接受安慰剂治疗（A组），另一组接受CDPc（1 g / d v.o。）（B组）。 {结果：}实验1的结果表明，静息状态下左颞下脑血流灌注不足，而在给药后观察到诱导的正常化。实验2的结果显示，A组的神经心理功能没有改善，而B组的记忆，学习过程和口语流利性在治疗后得到了显着改善。 {结论：} CDP-胆碱似乎是一种对与记忆相关的大脑区域具有特殊亲和力的药物，可在需要的地方起作用，使低灌注的左颞基底区域的血流正常化，并使神经心理学训练有效。通常，数据表明认知康复将遵循以下原则：首先恢复并维持病变部位的脑血流，然后再行使功能。在这项关于记忆康复的研究中，通过首先使病变部位的血流正常化并同时进行神经心理学训练，使记忆恢复成为可能。

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