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Killer flu's ancestor

机译:杀手流感的祖先

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It's the mother of deadly bird flu. A little-known chicken virus found across Eurasia has spawned another killer offspring - H10N8 -which has killed one person and made another critically ill in China. Crucially, H10N8 shares an ancestor with the other bird flus infecting people in the region, H5N1 and H7N9, deepening concerns that the ancestor virus could produce more killers. The common ancestor is a virus called H9N2. "H9N2 is the enabler, the one to worry about," Robert Webster of St Jude Children's Research Hospital in Memphis, Tennessee, told New Scientist. Bird flu usually infects the gut of ducks, but H9N2 has evolved into a benign respiratory virus in chickens, spreading across Eurasia. When multiple flu viruses infect the same host, they can swap genes. H5N1, H7N9 and H10N8 all got some or all of their "internal" genes from H9N2 -those for the enzymes that replicate the viral genome, for example, as opposed to those that code for surface proteins.
机译:这是致命的禽流感之母。在欧亚大陆发现的一种鲜为人知的鸡病毒催生了另一个杀手后代-H10N8-在中国杀死了一个人,并使另一人重病。至关重要的是,H10N8与其他禽流感共同感染该地区的人,即H5N1和H7N9,加深了人们对祖先病毒可能产生更多杀手的担忧。共同祖先是一种称为H9N2的病毒。田纳西州孟菲斯市圣裘德儿童研究医院的罗伯特·韦伯斯特对新科学家说:“ H9N2是使人担忧的因素。”禽流感通常会感染鸭子的肠道,但是H9N2已在鸡体内演变成一种良性呼吸道病毒,并在欧亚大陆传播。当多种流感病毒感染同一宿主时,它们可以交换基因。 H5N1,H7N9和H10N8都从H9N2获得了部分或全部“内部”基因-例如,那些复制病毒基因组的酶,与编码表面蛋白的酶相反。

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  • 来源
    《New scientist》 |2014年第2955期|6-6|共1页
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  • 收录信息 美国《科学引文索引》(SCI);美国《化学文摘》(CA);
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  • 正文语种 eng
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