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Aperiodic Deterministic Structure of OCD and the Familial Effect on Rituals

机译:OCD的非周期性确定性结构及其对仪式的家族效应

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A dynamical disease is one in which the symptoms appear and disappear over time in a deterministic pattern that could be chaotic. By determining the dynamic structure of the temporal pattern it would be possible to gain some insight into the triggers for symptoms if not the disease process as a whole. The present study investigated whether obsessive-compulsive disorder (OCD) could be considered a dynamical disease because of the intermittent outbursts of ritual behaviors. One-week diaries were collected from 17 clinical cases with 16 matched controls to record both the occurrence of rituals as they transpired over time and the influence the family may have had upon the spatiotemporal structure of symptoms. Comparisons of nonlinear regression parameters and Lyapunov exponents revealed that OCD exhibited a low-dimensional deterministic structure. The average nonlinear model (R~2 = 0.32) explained more than 10 times the variance of its linear counterpart (R~2 = 0.03). Family reactions and emotional responses accounted for only a very modest increase in the variance explained by the nonlinear regression model or in the amount of turbulence. Family reactions and emotional responses do little to make the rituals go away, but instead may strengthen the dynamics. Finally, significant rank order correlations were found between the R2 for the time series for each logbook and Lyapunov exponents with symptom severity and family reactions.
机译:动力性疾病是指症状随着时间的流逝而以一种可能是混乱的确定性模式出现和消失的疾病。通过确定时间模式的动态结构,即使不是整个疾病过程,也有可能深入了解症状的触发因素。本研究调查了强迫行为障碍(OCD)是否可以被认为是一种动态疾病,因为其间歇性的仪式行为爆发。从17例临床病例和16例相匹配的对照中收集了一周的日记,记录了随时间推移发生的仪式的发生情况以及家庭可能对症状的时空结构产生的影响。非线性回归参数和Lyapunov指数的比较表明,OCD表现出低维确定性结构。平均非线性模型(R〜2 = 0.32)解释了其线性对应方差(R〜2 = 0.03)的10倍以上。家庭反应和情绪反应仅占非线性回归模型解释的方差或湍流量的非常适度的增加。家庭反应和情感反应并不能使仪式消失,反而可以增强动力。最后,在每本日志的时间序列的R2与具有症状严重程度和家庭反应的Lyapunov指数之间发现了显着的排名相关性。

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