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Lifespan Characterization of Chaotic Dynamics in Menstruation

机译:月经混沌动力学的寿命表征

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摘要

In previous work, we found evidence that chaotic dynamics characterize the human menstrual cycle. Here, we examine chaotic dynamics in menstruation year-by-year over the lifespan, with special attention to later life. Using data in the Tremin research program archives, lifelong menstrual cycle histories known for 143 subjects beginning at about age 20 through the final menstrual period (FMP) provided data for time series analysis. Cycle lengths were aggregated and analyzed by year prior to the FMP. Time series data was analyzed with procedures developed by Grassberger-Procaccia and by Judd, and the results summarized by a new measure defined herein, the inter-event correlation parameter (I_(cp)). The menstrual cycle was characterized by chaotic dynamics rather than disorder or randomness throughout life until the FMP. Plots of the I_(cp) versus the number of years prior to the final menstrual period showed a small increase approximately 17 years prior to the final menstrual period and a large monotonic decrease during the last 5-8 years before the final menstrual period. The shifts in I_(cp) correspond in time to significant phenomena identified in menstruation research. Assumptions underlying the analysis are discussed in the article. Possible implications of these findings to paradigms of menopause are discussed.
机译:在以前的工作中,我们发现了证据表明混沌动力学是人类月经周期的特征。在这里,我们检查寿命中逐年逐月的混沌动力学,并特别注意以后的生活。利用Tremin研究计划档案中的数据,从约20岁开始到最后一个月经期(FMP)的143名受试者的终生月经周期历史记录为时间序列分析提供了数据。在进行FMP之前,按年汇总和分析周期长度。使用Grassberger-Procaccia和Judd开发的程序分析了时间序列数据,并通过此处定义的新度量(事件间相关参数(I_(cp)))汇总了结果。直到FMP为止,整个生命周期中的月经周期的特征都是混沌,而不是无序或随机。 I_(cp)与最终月经期前的年数的关系图显示,在最终月经期前约17年,I_(cp)略有增加,而在最后月经期前的最后5-8年中,单调性下降较大。 I_(cp)的变化在时间上对应于月经研究中发现的重要现象。本文讨论了该分析所基于的假设。讨论了这些发现对更年期范式的可能含义。

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