Design of a tracking device for on-line dose monitoring in hadrontherapy

G. Battistoni; F. Collamati; E. De Lucia; R. Faccini; M. Marafini; I. Mattel; S. Muraro; R. Paramatti; V. Patera; D. Pinci; A. Rucinski; A. Russomando; A. Sarti; A. Sciubba; E. Solfaroli Camillocci; M. Toppi; G. Traini; C. Voena

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Design of a tracking device for on-line dose monitoring in hadrontherapy

机译：强子疗法中剂量在线监测装置的设计

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摘要

Hadrontherapy is a technique for cancer treatment that exploits ion beams (mostly protons and carbons). A critical issue is the accuracy that is achievable when monitoring the dose released by the beam to the tumor and to the surrounding tissues. We present the design of a tracking device, developed in the framework of the INSIDE project [1], capable of monitoring in real time the longitudinal profile of the dose delivered in the patient. This is possible by detecting the secondary particles produced by the interaction of the beam in the tissues. The position of the Bragg peak can be correlated to the charged particles emission point distribution measurement. The tracking device will be able to provide a fast response on the dose pattern by tracking the secondary charged fragments. The tracks are detected using 6 planes of scintillating fibers, providing the 3D coordinates of the track intersection with each plane. The fibers planes are followed by a plastic scintillator and by a small calorimeter built with a pixelated Lu-tetium Fine Silicate (LFS) crystal. A complete detector simulation, followed by the event reconstruction, has been performed to determine the achievable monitoring spatial resolution.

机译：强子疗法是一种利用离子束（主要是质子和碳）进行癌症治疗的技术。一个关键问题是在监视光束释放到肿瘤和周围组织的剂量时可达到的精度。我们介绍了在INSIDE项目[1]的框架中开发的跟踪设备的设计，该设备能够实时监控在患者体内输送的剂量的纵向分布。这可以通过检测由光束在组织中的相互作用产生的次级粒子来实现。布拉格峰的位置可以与带电粒子发射点分布测量相关。跟踪装置将能够通过跟踪次级带电碎片来对剂量模式提供快速响应。使用6个闪烁纤维平面检测轨道，并提供轨道与每个平面相交的3D坐标。纤维平面之后是塑料闪烁体，以及装有像素化Lu细硅酸盐（LFS）晶体的小型量热仪。已经执行了完整的探测器仿真，然后进行事件重建，以确定可实现的监视空间分辨率。

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来源
《Nuclear Instruments & Methods in Physics Research》 |2017年第11期|679-683|共5页
作者
G. Battistoni; F. Collamati; E. De Lucia; R. Faccini; M. Marafini; I. Mattel; S. Muraro; R. Paramatti; V. Patera; D. Pinci; A. Rucinski; A. Russomando; A. Sarti; A. Sciubba; E. Solfaroli Camillocci; M. Toppi; G. Traini; C. Voena;
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作者单位

INFN Sezione di Milano, Milano, Italy;

Laboratori Nazionali di Frascati dell'INFN, Frascati, Italy;

Laboratori Nazionali di Frascati dell'INFN, Frascati, Italy;

Dipartimento di Fisica, 'La Sapienza' Universita di Roma, Roma, Italy,INFN Sezione di Roma, Roma, Italy;

INFN Sezione di Roma, Roma, Italy,Museo Storico della Fisica e Centra Studi e Ricerche "E. Fermi", Roma, Italy;

INFN Sezione di Milano, Milano, Italy;

INFN Sezione di Milano, Milano, Italy;

INFN Sezione di Roma, Roma, Italy;

INFN Sezione di Roma, Roma, Italy,Museo Storico della Fisica e Centra Studi e Ricerche "E. Fermi", Roma, Italy,Dipartimento di Scienze di Base e Applicate per Ingegneria, "La Sapienza" Universita di Roma, Roma, Italy;

INFN Sezione di Roma, Roma, Italy;

INFN Sezione di Roma, Roma, Italy,Dipartimento di Scienze di Base e Applicate per Ingegneria, "La Sapienza" Universita di Roma, Roma, Italy;

Dipartimento di Fisica, 'La Sapienza' Universita di Roma, Roma, Italy,INFN Sezione di Roma, Roma, Italy,Center for Life Nano Science@Sapienza, Istituto Italiano di Tecnologia, Roma, Italy;

INFN Sezione di Roma, Roma, Italy,Museo Storico della Fisica e Centra Studi e Ricerche "E. Fermi", Roma, Italy,Dipartimento di Scienze di Base e Applicate per Ingegneria, "La Sapienza" Universita di Roma, Roma, Italy;

INFN Sezione di Roma, Roma, Italy,Museo Storico della Fisica e Centra Studi e Ricerche "E. Fermi", Roma, Italy,Dipartimento di Scienze di Base e Applicate per Ingegneria, "La Sapienza" Universita di Roma, Roma, Italy;

Dipartimento di Fisica, 'La Sapienza' Universita di Roma, Roma, Italy,INFN Sezione di Roma, Roma, Italy;

Laboratori Nazionali di Frascati dell'INFN, Frascati, Italy;

Dipartimento di Fisica, 'La Sapienza' Universita di Roma, Roma, Italy,INFN Sezione di Roma, Roma, Italy;

INFN Sezione di Roma, Roma, Italy;

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正文语种 eng
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关键词
Hadrontherapy; Dose monitoring; Quality assurance; Ion beam; Secondary charged particles; Tracking device;

机译：强子疗法;剂量监测;质量保证;离子束二次带电粒子;跟踪装置;

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3. Imaging issues specific to hadrontherapy (proton, carbon, helium therapy and other charged particles) for radiotherapy planning, setup, dose monitoring and tissue response assessment [J] . Thariat J., Herault J., Beddok A., Cancer radiotherapie: journal de la Soci閠?fran鏰ise de radiotherapie oncologique . 2020,第5期

机译：针对HATRONTHERAPACY（质子，碳，氦治疗等带电粒子）的成像问题用于放射治疗计划，设置，剂量监测和组织反应评估
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5. Total Dose Effects and Hardening-by-Design Methodologies for Implantable Medical Devices. [D] . Schlenvogt, Garrett. 2010

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6. Design and prototype of a mechanism for active on-line emergingotifiable infectious diseases control tracking and surveillance based on a national healthcare card system [O] . Jyh-Win Huang, Ting-Wei Hou -1

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7. Measurement of charged particle yields from therapeutic beams in view of the design of an innovative hadrontherapy dose monitor [O] . Battistoni, G., Bellini, F., Bini, F., 2015

机译：借助创新的强子疗法剂量监测器的设计，可测量治疗束带电粒子的产量

Design of a tracking device for on-line dose monitoring in hadrontherapy

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