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Sentinel lymph node biopsy in patient with melanoma

机译：黑色素瘤患者前哨淋巴结活检

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摘要

Cutaneous melanoma incidence has been increasing last 3 decades. Despite recent improvements in treatments, metastatic disease prognosis remains unfavorable. Lymph node involvement is a major prognosis factor in melanoma, and sentinel lymph node (SLN) biopsy becomes an essential procedure for nodal staging. SLN biopsy is available in most surgical cancer departments but procedure needs very strict achievement guidelines to allow a high level of performance. SLN biopsy could detect a prospective lymph node involvement with very high accuracy, along with very low morbidity. So, lymph node dissection would be performed only in a limited number of patients, increasing their disease free survival. However, in case of positive SLN, lymph node dissection interest as therapeutic act is still under debate and, in the future, indications of lymph node dissections will be purposed more accurately according to prognosis factors, especially histologic SLN analysis. Up to now, adjuvant treatments in melanoma were disappointing but new promising molecules are under research. According to researches results, SLN biopsy will probably allow a better selection of patients who should get benefit of those treatments. (C) 2015 Elsevier Masson SAS. All rights reserved.
机译：皮肤黑素瘤的发病率最近3年一直在增加。尽管最近在治疗方面已有改进，但转移性疾病的预后仍然不利。淋巴结受累是黑色素瘤的主要预后因素，前哨淋巴结（SLN）活检成为淋巴结分期的必要程序。 SLN活检可用于大多数外科癌症科室，但手术过程需要非常严格的成就准则，以实现较高水平的表现。前哨淋巴结活检可以非常准确地检测到预期的淋巴结受累，而且发病率也很低。因此，仅在有限数量的患者中进行淋巴结清扫术，从而增加了他们的无病生存期。然而，在SLN阳性的情况下，关于淋巴结清扫作为治疗手段的兴趣仍在争论中，将来，根据预后因素，尤其是组织学SLN分析，将更准确地针对淋巴结清扫的指征。迄今为止，黑素瘤的辅助治疗令人失望，但新的有希望的分子正在研究中。根据研究结果，SLN活检可能会更好地选择应从这些治疗中受益的患者。 （C）2015 Elsevier Masson SAS。版权所有。

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  • 来源
    《Medecine Nucleaire》 |2015年第3期|339-347|共9页
  • 作者

    Bourre J. -C.; Brard P. -Y.; Charles J.; Stella M.; Rouet C.; Andreani R.; Francois-Joubert A.;

  • 作者单位

    Ctr Hosp Metropole Savoie, Nucl Med Serv, F-73000 Chambery, France|Univ Grenoble, INSERM, U1039, Lab Radiopharmaceut Bioclin, F-38000 Grenoble, France;

    Ctr Hosp Metropole Savoie, Nucl Med Serv, F-73000 Chambery, France;

    CHU Grenoble, Clin Univ Dermatol, F-38000 Grenoble, France|Univ Grenoble 1, INSERM, U823, F-38000 Grenoble, France;

    Ctr Hosp Metropole Savoie, Serv Chirurg Viscerale & Endocrinienne, F-73000 Chambery, France;

    Ctr Hosp Metropole Savoie, Serv Radiopharm, F-73000 Chambery, France;

    Ctr Hosp Metropole Savoie, Nucl Med Serv, F-73000 Chambery, France;

    Ctr Hosp Metropole Savoie, Nucl Med Serv, F-73000 Chambery, France;

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  • 原文格式 PDF
  • 正文语种 fre
  • 中图分类
  • 关键词

    Melanoma; Sentinel lymph node; Lymphatic mapping; Micrometastasis; SPECT-CT;

    机译：黑色素瘤;前哨淋巴结;淋巴标测;微转移;SPECT-CT;

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