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Unravelling the connection between metabolism, cell growth and cancer

机译:揭示新陈代谢,细胞生长与癌症之间的联系

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This paper presents a short review of the up-to-date literature on the connection between metabolism, cell growth and cancer. A major link is aerobic glycolysis, a phenomenon termed "the Warburg effect", and we describe its relationship with cellular redox balance that promotes faster proliferation of cancer cells and could lead to new therapeutic approaches. We analyse signals that accelerate cancer, namely insulin and insulin-like growth factor and we briefly describe signalling pathways related to growth factor receptors. We focus on the important part played by the PI3K/Akt signalling pathway and we discuss the major role played by PTEN and treatment approaches that might result. (C) 2015 Elsevier Masson SAS. All rights reserved.
机译:本文简要介绍了有关代谢,细胞生长和癌症之间关系的最新文献。一个主要的联系是有氧糖酵解,这种现象被称为“ Warburg效应”,我们描述了它与细胞氧化还原平衡的关系,该平衡促进癌细胞的更快增殖并可能导致新的治疗方法。我们分析加速癌症的信号,即胰岛素和类胰岛素生长因子,并简要描述与生长因子受体相关的信号通路。我们专注于PI3K / Akt信号通路所起的重要作用,并讨论PTEN所起的主要作用以及可能产生的治疗方法。 (C)2015 Elsevier Masson SAS。版权所有。

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