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首页> 外文期刊>Medecine Nucleaire >Quantification of the Thyroid Scan (TS) and correlation to Multiparametric Ultrasounds (MPUS): A textbook case of nuclear molecular imaging
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Quantification of the Thyroid Scan (TS) and correlation to Multiparametric Ultrasounds (MPUS): A textbook case of nuclear molecular imaging

机译：甲状腺扫描（TS）的定量和与多体超声波（MPU）的相关性：核分子成像的教科书案例

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For decades, thyroid scintigraphy (TS) has been considered an interesting tool, especially in the field of hyperthyroidism. In recent years, TS has rapidly gained importance since it provides unique molecular information that cannot be obtained by any other modality. In fact, despite a limited 6 mm spatial resolution, it can highlight molecular and histo-functional changes that characterize most thyroid function disorders. However, to become such a powerful molecular image, the TS must be quantified. How much iodine is taken-up characterizes the Uptake (Up), while where iodine distributes characterizes the Spatial Targeting (ST). Methodology, results and limits of the thyroid Uptake are presented, including suppressed tests. Methods to determine the anatomical thyroid volume are revisited with special focus on planar scintigraphy. Recent developments in quantification make the I-123-TS a new molecular imaging procedure. Since I-123 targets the sodium iodide symporter (NIS) and tracks the whole organification process, we derived a fundamental linear relationship between the TSH and the precocious (120-240 min) Uptake (p(123)IUp). This relationship indicates whether the I-123 input follows the physiological TSH stimulation or is predictive of a non TSH-suppressible function, whatever the imaging pattern. This allows identification of toxic or compensated (TSH 0.1 mU/L) Thyroid Functional Autonomy (TFA), even at baseline. Spatial Targeting, measured with the aid of computational algorithms, provides a reproducible Spatial Targeting Index (STI). This allows estimating a functional thyroid volume, that is likely more informative than the anatomical one. Most aspects of TS quantification and the interest to compare the structure (mostly MultiParametric US) and the function (molecular I-123-TS) are presented. (C) 2020 Published by Elsevier Masson SAS.
机译：几十年来，甲状腺闪烁图（TS）被认为是一个有趣的工具，特别是在甲状腺功能亢进的领域。近年来，TS快速获得了重要性，因为它提供了任何其他方式无法获得的独特分子信息。事实上，尽管存在有限的6 mm空间分辨率，但它可以突出分子和组织功能变化，其表征大多数甲状腺功能障碍。然而，为了成为这种强大的分子图像，必须量化TS。吸收多少碘表征摄取（向上），而碘分布表征空间靶向（ST）。提出了甲状腺摄取的方法，结果和限制，包括抑制试验。确定解剖学甲状腺体积的方法重新审视平面闪烁图。定量的最新发展使I-123-TR成为新的分子成像程序。由于I-123靶向碘化钠交易者（NIS）并跟踪整个组织过程，我们源于TSH和早熟（120-240分钟）摄取（P（123）IUP）之间的基本线性关系。无论成像模式如何，这种关系指示I-123输入是否遵循生理TSH刺激或预测非TSH抑制功能。这允许鉴定毒性或补偿（TSH>0.1μ/升）甲状腺功能性自主性（TFA），即使在基线时也是如此。借助计算算法测量的空间靶向提供可再现的空间靶向指数（STI）。这允许估计功能性甲状腺体积，其可能比解剖学更具信息性。提出了TS量化的大多数方面和比较结构（大多数Multiparametric US）和功能（分子I-123-TS）的兴趣。 （c）2020由Elsevier Masson SA发表。

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