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Colorectal cancer stage evaluation using synchronous fluorescence spectroscopy technique

机译：同步荧光光谱技术评估大肠癌分期

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摘要

In our study we investigate the characteristic differences, with diagnostic meaning, in the synchronous fluorescence spectra (SFS) of cancerous and healthy colorectal tissues, ex vivo. The main observed fluorophores which fluorescence has a diagnostic meaning are tyrosine, tryptophan, NADH, FAD, collagen, elastin, and por-phyrines. In the SFS of three colorectal tumours and healthy tissue originated from one patient we observed the formation of alterations in the fluorescence, which can be addressed to specific dysplastic changes in the tissues and could be used for tumour stage evaluation.
机译：在我们的研究中，我们调查了癌性和健康结直肠组织的同步荧光光谱（SFS）在体外的特征差异，并具有诊断意义。观察到的具有荧光意义的主要荧光团是酪氨酸，色氨酸，NADH，FAD，胶原蛋白，弹性蛋白和卟啉。在源自一名患者的三种结直肠肿瘤和健康组织的SFS中，我们观察到了荧光的变化，这可以解决组织中特定的增生异常变化，并可以用于肿瘤分期评估。

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  • 来源
    《Optical and quantum electronics》 |2016年第8期|378.1-378.10|共10页
  • 作者

    Ts. Genova; E. Borisova; Al. Zhelyazkova; N. Penkov; B. Vladimirov; I. Terziev; O. Semyachkina-Glushkovskaya; L. Avramov;

  • 作者单位

    Institute of Electronics, Bulgarian Academy of Sciences, 72, Tsarigradsko chaussee Blvd., 1784 Sofia, Bulgaria;

    Institute of Electronics, Bulgarian Academy of Sciences, 72, Tsarigradsko chaussee Blvd., 1784 Sofia, Bulgaria;

    Institute of Electronics, Bulgarian Academy of Sciences, 72, Tsarigradsko chaussee Blvd., 1784 Sofia, Bulgaria;

    University Hospital 'Tsaritsa Yoanna-ISUL', 8, Byalo more str., 1572 Sofia, Bulgaria;

    University Hospital 'Tsaritsa Yoanna-ISUL', 8, Byalo more str., 1572 Sofia, Bulgaria;

    University Hospital 'Tsaritsa Yoanna-ISUL', 8, Byalo more str., 1572 Sofia, Bulgaria;

    Biology Department, Saratov State University, Physiology of Human and Animals lab., 83 Astrakhanskaya str., Saratov, Russia;

    Institute of Electronics, Bulgarian Academy of Sciences, 72, Tsarigradsko chaussee Blvd., 1784 Sofia, Bulgaria;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Synchronous fluorescence spectroscopy; Cancer; Diagnostics;

    机译：同步荧光光谱法;癌症;诊断程序;

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