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首页> 外文期刊>Optical and quantum electronics >Tomographic imaging of collagen fiber orientation in human tissue using depth-resolved polarimetry of second-harmonic-generation light
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Tomographic imaging of collagen fiber orientation in human tissue using depth-resolved polarimetry of second-harmonic-generation light

机译：使用二次谐波产生光的深度分辨偏振法对人体组织中的胶原纤维取向进行层析成像

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摘要

We propose a nonlinear optical probe method to image the distribution of collagen fiber orientation in human tissue by measuring the polarization of collagen-induced second-harmonic-generation (SHG) light (SHG polarimetry). Depth-resolved SHG polarimetry, with a depth resolution of 14 μm, was used to evaluate the cross-sectional profile of collagen fiber orientation in Achilles tendon and dentin, revealing a characteristic distribution of collagen orientation along the depth direction. We evaluated the two-dimensional (2D) lateral distribution of collagen fiber orientation in back reticular dermis and ankle-bone by polarization-resolved SHG imaging, and confirmed an appreciable difference in the distribution profiles of the two samples. We further extended the method to a depth-resolved measurement of the three-dimensional (3D) distribution of collagen orientation in anklebone. The proposed system promises to be a powerful tool for in vivo measurement of collagen fiber orientation in human tissue.
机译：我们提出了一种非线性光学探针方法，通过测量胶原诱导的第二谐波产生（SHG）光的偏振（SHG旋光法）来成像人体组织中的胶原纤维取向分布。深度分辨SHG旋光仪的深度分辨率为14μm，用于评估跟腱和牙本质中胶原纤维取向的横截面轮廓，揭示了沿深度方向的胶原取向特征分布。我们通过极化分辨SHG成像评估了网状真皮层和踝骨中胶原纤维取向的二维（2D）横向分布，并确认了这两个样品的分布曲线存在明显差异。我们进一步扩展了该方法的深度分辨率，以测量踝骨中胶原蛋白取向的三维（3D）分布。拟议的系统有望成为人体组织中胶原纤维取向体内测量的有力工具。

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