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A theoretical proposal of high performance blood components biosensor based on defective 1D photonic crystal employing WS_2, MoS_2 and graphene

机译:基于缺陷的1D光子晶体采用WS_2,MOS_2和石墨烯的高性能血液成分生物传感器的理论提出

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摘要

In this research, a novel configuration of 1D photonic crystal (PhC) is proposed for the detection of numerous elements present in human blood such as plasma, RBC, biotin, serum albumin. The proposed structure is envisaged with an alternate arrangement of CaF_2, PtSe_2 and ZnSe with a central defect layer, where the wall of the defect layer is separately coated with novel 2D materials like WS_2, MoS_2 and graphene to enhance the sensor performance. The well-known transfer matrix method (TMM) is employed to compute the transmission spectrum and absorption spectrum by infiltrating the defect layer with blood components. The cornerstone of this work is to observe the shift in the defect mode wavelength in the transmission spectrum. The geometrical parameters of the structure such as thickness of dielectric layers, defect layer, refractive index of dielectric layers and the number of period are judiciously optimized to realize effective sensor. The effect of variation in the defect layer thickness and angle of incidence on the transmission spectrum is thoroughly studied. Additionally, the number of layers of WS_2, MoS_2 and graphene are suitably optimized for design of high performance biosensor. Various sensing characteristics such as sensitivity, signal-to-noise ratio (SNR), quality factor (QF), figure of merit (FOM), resolution and detection limit (DL) are evaluated and compared for the proposed WS_2, MoS_2 and graphene based sensor configurations. Moreover, the simple structure, cost-effective fabrication methods and label-free detection of blood components make the proposed sensor a promising challenger for biosensing applications.
机译:在该研究中,提出了一种新颖的光子晶体(PHC)的配置,用于检测人血液中存在的许多元素,例如血浆,RBC,生物素,血清白蛋白。所提出的结构以CAF_2,PTSE_2和ZnSE的交替布置设想,其中具有中央缺陷层,其中缺陷层的壁分别用新的2D材料如WS_2,MOS_2和石墨烯涂覆,以增强传感器性能。使用众所周知的转移矩阵方法(TMM)来计算通过用血液成分渗透缺陷层来计算透射谱和吸收光谱。这项工作的基石是在传输频谱中观察缺陷模式波长的偏移。结构的几何参数,例如介电层的厚度,缺陷层,介电层的折射率和周期的数量是明智地优化的,以实现有效的传感器。彻底研究了缺陷层厚度和发射角度的变化的影响。另外,WS_2,MOS_2和石墨烯的层数适当优化,用于设计高性能生物传感器。评估各种感测特性,例如灵敏度,信噪比(SNR),质量因数(QF),优点(FOM),分辨率和检测极限(DL),并比较了所提出的WS_2,MOS_2和石墨烯传感器配置。此外,简单的结构,具有成本效益的制造方法和无标记的血液组件检测使得提出的传感器成为生物传感器应用的承诺挑战者。

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