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首页> 外文期刊>Optical engineering >Numerical modeling of graphene-coated fiber optic surface plasmon resonance biosensor for BRCA1 and BRCA2 aenetic breast cancer detection
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Numerical modeling of graphene-coated fiber optic surface plasmon resonance biosensor for BRCA1 and BRCA2 aenetic breast cancer detection

机译：BRCA1和BRCA2乳腺癌检测的石墨烯涂层光纤表面等离子传感器的数值模拟

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A numerical illustration of a hybrid design and numerical analysis of graphene-coated fiber-optic surface plasmon resonance (SPR) biosensor for BRCA-1 and BRCA-2 genetic breast cancer detection is provided. Two specific mutations named 916delTT in BRCA-1 gene and 6174delT in BRCA-2 gene are being selected for detection of breast cancer numerically. This sensor is based on attenuated total reflection (ATR) method to detect individual point mutations in BRCA-1 and BRCA-2 genes. Based on the numerically obtained results, a momentous change is present in the SPR angle (minimum 35% more) and surface resonance frequency (SRF) (minimum 36% more) for probe DNA with various concentrations of target DNA corresponding to the mutation of the BRCA-1 and BRCA-2 genes. The variation of the SPR angle and SRF for mismatched DNA strands in BRCA-1 and BRCA-2 genes is quite negligible, whereas that for complementary DNA strands is considerable. This considerable change is essential for proper detection of genetic biomarkers (916delTT and 6174delT) for early breast cancer. To the best of our knowledge, this is the first demonstration of such an adept biosensor for detecting BRCA1 and BRCA2 genetic breast cancer. Here, we used graphene as bimolecular acknowledgement element for improving sensor performance. At the end of the article, the performance in terms of sensitivity is analyzed. Therefore, the proposed biosensor opens a window toward detection of early detection of BRCA-1 and BRCA-2 genetic breast cancers.
机译：提供了Braphene涂层纤维表面等离子体共振（SPR）生物传感器的混合设计和数值分析的数值例证，用于BRCA-1和BRCA-2遗传乳腺癌检测。选择在BRCA-1基因916deltt中命名的两种特异性突变，在BRCA-2基因中进行6174钟，用于在数值上检测乳腺癌。该传感器基于衰减的全反射（ATR）方法来检测BRCA-1和BRCA-2基因中的单独点突变。基于数值获得的结果，对于具有各种浓度的靶DNA对应于突变的靶DNA的探针DNA，在SPR角度（最小35％）和表面共振频率（SRF）中（SRF）（最小36％更多）存在，存在重大变化BRCA-1和BRCA-2基因。在BRCA-1和BRCA-2基因中对不匹配的DNA链的SPR角和SRF的变化是非常可忽略的，而对于互补的DNA链是相当大的。这种相当大的变化对于适当检测早期乳腺癌的遗传生物标志物（916deltt和6174delt）至关重要。据我们所知，这是第一次证明这种Adept生物传感器，用于检测BRCA1和BRCA2遗传乳腺癌。在这里，我们使用石墨烯作为共分子确认元件，用于改善传感器性能。在本文结束时，分析了敏感性的性能。因此，所提出的生物传感器打开朝向检测BRCA-1和BRCA-2遗传乳腺癌的早期检测的窗口。

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