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首页> 外文期刊>Optical engineering >Frequency-domain multichannel optical detector for noninvasive tissue spectroscopy and oximetry
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Frequency-domain multichannel optical detector for noninvasive tissue spectroscopy and oximetry

机译：用于无创组织光谱学和血氧测定法的频域多通道光学检测器

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摘要

We have designed a multisource frequency-domain spectrom-eter for the optical study of biological tissues. Eight multiplexed, intensity-modulated LEDs are employed as the light sources. Four of them emit light at a peak wavelength of 715 nm (λ_1); the other four, 850 nm (λ_2). The frequency of intensity modulation is 120 MHz. This instrument measures the frequency-domain parameters phase, dc intensity, and ac amplitude at the two wavelengths λ_1 and λ_2 and for different distances between light source and detector. From these frequency-domain raw data, the absolute values of the absorption and reduced scattering coefficients of tissue at λ_1 and λ_2 are obtained. The oxy- and deoxyhemoglobin concentrations, and hence the hemoglobin saturation, are then analytically derived from the molar extinction coefficients. Acquisition times as short as hundreds of milliseconds provide real-time monitoring of the measured parameters. We performed a systematic test in vitro to quantify the precision and accuracy of the instrument reading. We also report in vivo measurements. This spectrometer can be packaged as a compact portable unit.
机译：我们设计了一种用于生物组织光学研究的多源频域光谱仪。八个多路复用的，强度调制的LED被用作光源。其中四个以峰值波长715 nm（λ_1）发出光。其他四个波长为850 nm（λ_2）。强度调制的频率为120 MHz。该仪器在两个波长λ_1和λ_2以及光源和检测器之间的不同距离下测量频域参数的相位，直流强度和交流幅度。从这些频域原始数据中，获得组织在λ_1和λ_2处的吸收系数和减小的散射系数的绝对值。然后从摩尔消光系数中分析得出氧合和脱氧血红蛋白的浓度，从而使血红蛋白饱和。采集时间短至数百毫秒，可实时监控测量的参数。我们在体外进行了系统的测试，以量化仪器读数的准确性和准确性。我们还报告了体内测量。该光谱仪可以包装为紧凑的便携式单元。

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