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首页> 外文期刊>Optical engineering >Geometrical effect characterization of femtosecond-laser manufactured glass microfluidic chips based on optical manipulation of submicroparticles
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Geometrical effect characterization of femtosecond-laser manufactured glass microfluidic chips based on optical manipulation of submicroparticles

机译：飞秒激光制造的玻璃微流控芯片基于亚微粒的光学操纵的几何效应表征

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摘要

Microfluidic devices provide a platform with wide ranging applications from environmental monitoring to disease diagnosis. They offer substantive advantages but are often not optimized or designed to be used by nonexpert researchers. Microchannels of a microanalysis platform and their geometrical characterization are of eminent importance when designing such devices. We present a method that is used to optimize each micro-channel within a device using high-throughput particle manipulation. For this purpose, glass-based microfluidic devices, with three-dimensional channel networks of several geometrical sizes, were fabricated by employing laser fabrication techniques. The effect of channel geometry was investigated by employing an optical tweezer. The optical trapping force depends on the flow velocity that is associated with the dimensions of the microchan-nel. We observe a linear dependence of the trapping efficiency and of the fluid flow velocity, with the channel dimensions. We determined that the highest trapping efficiency was achieved for microchannels with aspect ratio equal to one. Numerical simulation validated the impact of the device design dimensions on the trapping efficiency. This investigation indicates that the geometrical characteristics, the flow velocity, and trapping efficiency are crucial and should be considered when fabricating microfluidic devices for cell studies.
机译：微流体设备为从环境监测到疾病诊断的广泛应用提供了平台。它们提供了实质性的优势，但通常没有经过优化或设计以供非专业研究人员使用。在设计此类设备时，微分析平台的微通道及其几何特征非常重要。我们提出了一种使用高通量粒子处理技术来优化设备中每个微通道的方法。为此，通过采用激光制造技术来制造具有几种几何尺寸的三维通道网络的玻璃基微流体装置。通过使用光学镊子研究了通道几何形状的影响。光学捕获力取决于与微通道尺寸相关的流速。我们观察到捕集效率和流体流速与通道尺寸之间的线性关系。我们确定纵横比等于1的微通道实现了最高捕获效率。数值模拟验证了器件设计尺寸对捕集效率的影响。这项研究表明，几何特征，流速和捕集效率至关重要，在制造用于细胞研究的微流体装置时应予以考虑。

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  • 来源
    《Optical engineering》 |2017年第12期|124111.1-124111.6|共6页
  • 作者

    Domna G. Kotsifaki; Mark D. Mackenzie; Georgia Polydefki; Ajoy K. Kar; Mersini Makropoulou; Alexandras A. Serafetinides;

  • 作者单位

    National Technical University of Athens, Physics Department, Laboratory of Optoelectronics, Lasers and their Applications, Athens, Greece;

    Heriot-Watt University, Institute of Photonics and Quantum Sciences, School of Engineering and Physical Sciences, Non-Linear Optics Group, Edinburgh, United Kingdom;

    National Technical University of Athens, Physics Department, Laboratory of Optoelectronics, Lasers and their Applications, Athens, Greece;

    Heriot-Watt University, Institute of Photonics and Quantum Sciences, School of Engineering and Physical Sciences, Non-Linear Optics Group, Edinburgh, United Kingdom;

    National Technical University of Athens, Physics Department, Laboratory of Optoelectronics, Lasers and their Applications, Athens, Greece;

    National Technical University of Athens, Physics Department, Laboratory of Optoelectronics, Lasers and their Applications, Athens, Greece;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    femtosecond laser; microfluidics; optical tweezers; glasses; geometrical characteristics; velocity measurements;

    机译：飞秒激光微流体光学镊子;眼镜;几何特征速度测量;

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