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Temperature monitoring of tumor hyperthermal treatments with optical fibers: comparison of distributed and quasi-distributed techniques

机译：具有光纤的肿瘤高热处理的温度监测：分布式和准分布式技术的比较

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摘要

Optical fiber based sensors capable of measuring temperature distribution over a given length are particularly attractive in the biomedical field, especially in the case of real-time monitoring of minimally invasive hyperthermal treatments of tumors, such as laser ablation, given their intrinsic multiplexing along a single fiber span and the unique properties of optical fibers in terms of flexibility, size and electromagnetic compatibility. The paper compares two sensing approaches: one is based on an array of Bragg gratings inscribed in the core of a single-mode fiber, the other detects Rayleigh backscattering from an unmodified single-mode fiber using coherent optical frequency domain reflectometry. Following an introduction, which describes the most distinctive features of the two approaches, the paper presents three comparative experiments, each devised to highlight a peculiar aspect of the sensors. In the first experiment the sensors are exposed to various constant temperature distributions to evaluate the uniformity of the readings along the fiber length. In the second experiment, a known temperature profile is generated through an ad hoc setup to evaluate the actual capability of the two approaches to reconstruct the temperature distribution. Finally, in the third experiment the two sensors are employed in a simulated tumor laser ablation procedure to measure the temperature distribution in the irradiated area. Both sensors provide results whose error, mainly due to cross sensitivity between temperature and strain, is acceptable for the considered biomedical application.
机译：能够在给定长度上测量温度分布的光纤基传感器在生物医学领域特别吸引，特别是在实时监测诸如激光烧蚀的微创的肿瘤的微创高热处理，鉴于它们的内在复用沿着单一的内在复用在柔韧性，尺寸和电磁兼容性方面，光纤跨度和光纤的独特性能。本文比较了两个传感方法：一个是基于一系列布拉格光栅铭刻在单模光纤的核心中，另一个是使用相干光学频率域反射测缝从未经修改的单模光纤中检测瑞利反向散射。介绍了描述了两种方法最独特的特征，本文呈现了三个比较实验，每个实验设计为突出传感器的特殊方面。在第一次实验中，传感器暴露于各种恒温分布，以评估沿纤维长度的读数的均匀性。在第二实验中，通过Ad Hoc设置产生已知的温度分布，以评估两种方法重建温度分布的实际能力。最后，在第三实验中，在模拟肿瘤激光消融过程中使用两个传感器以测量照射区域中的温度分布。两个传感器都提供了结果，主要是由于温度和应变之间的交叉敏感性，所考虑的生物医学应用是可接受的。

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