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Comparison of fluorescence tomographic imaging in mice with early-arriving and quasi-continuous-wave photons

机译:早期到达和准连续波光子在小鼠体内的荧光层析成像的比较

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摘要

The highly diffuse nature of light propagation in biological tissue is a major challenge for obtaining highfidelitynfluorescence tomographic images. In this work we investigated the use of time-gated detection ofnearly-arriving photons for reducing the effects of light scatter in mice relative to quasi-cw photons. Whennanalyzing sinographic representations of the measured data, it was determined that early photons allowedna reduction in the measured FWHM of fluorescent targets by a factor of approximately 2–3, yielding a significantnimprovement in the tomographic image reconstruction quality. © 2010 Optical Society of America
机译:光在生物组织中传播的高度扩散性是获得高保真度荧光层析成像图像的主要挑战。在这项工作中,我们研究了近门光子的时间门控检测相对于准CW光子在小鼠中减少光散射效应的用途。在分析测量数据的正弦图像表示时,可以确定,早期的光子可使荧光靶标的FWHM降低约2-3倍,从而显着提高了断层图像重建质量。 ©2010美国眼镜学会

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    《Optics Letters》 |2010年第3期|p.1-3|共3页
  • 作者单位

    Mark Niedre1,3 and Vasilis Ntziachristos2,3,*1Department of Electrical and Computer Engineering, Northeastern University, Boston, Massachusetts 02115, USA2Institute for Biological and Medical Imaging, Technical University of Munich and Helmholtz Center Munich,Ismaningerstrasse 21, D-85764 Munich, Germany3Laboratory for Biooptics and Molecular Imaging, Center for Molecular Imaging Research,Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA*Corresponding author: v.ntziachristos@tum.de;

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